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Eileen M. Handberg, PhD, ARNP

Eileen M. Handberg, PhD, ARNP-BC, FACC
Research Professor of Medicine
Director, Clinical Trials Program
Program Director, Florida CARES


TEL: 352.265.0820
CLINIC FAX: 352.627.4293

ADMIN: 352.273.9082





BSN Florida State University Nursing
MSN University of Florida Nursing
PhD University of Florida Nursing

Academic/Research Interests

Dr. Handberg is a Research Professor of Medicine and Director of the Cardiovascular Clinical Trials Program in the Division of Cardiovascular Medicine. She also serves the University as an Institutional Review Board member, and representative on the College of Medicine Continuing Medical Education committee. She is an Adult Nurse Practitioner and has an outpatient practice, and manages research patient care. She is program Director for the practitioner competency assessment program Florida CARES, one of only 7 Assessment Centers in the US.

An active member and current Trustee of the American College of Cardiology, Dr. Handberg serves on several committees including the ACC Scientific Sessions planning committee, PC3, Compensation, Metabolic Work Group, and is a member of the CV Team Council leadership group. She is the co-director of the ACC Core Curriculum for the Cardiovascular Clinician program, and served as co-chair of the Team-Based Work Group. She has served on several Presidential appointed committees including the search committee for the JACC Editor, and CEO search committee. She was the past Chair of the Nurse Education Committee, and has served on the Accreditation, BPQI committees and Anticoagulation Task Force. In 2009 she qualified for the designation FACC and was the first nurse (CCA) to achieve this recognition. Additionally she is a member of the American Heart Association’s Council on Cardiovascular Nursing and the Preventive Cardiovascular Nurses Association (PCNA), and is program director for the Vascular Biology Working Group (VBWG). She has contributed to over 90 articles, featured in the Journal of the American College of Cardiology, JAMA, Circulation, and the Journal of Women’s Health, among others.

Clinical Interests

  • Exercise & Lifestyle Interventions
  • Ischemic Heart Disease
  • Heart Disease in Women
  • Heart Failure


  • Hwang CL, Yoo JK, Kim HK, Hwang MH, Handberg EM, Petersen JW, Christou DD. Novel all-extremity high-intensity interval training improves aerobic fitness, cardiac function and insulin resistance in healthy older adults. Exp Gerontol. 2016 Jun 21. pii: S0531-5565(16)30170-X. doi: 10.1016/j.exger.2016.06.009. PubMed
  • Smith SM, Huo T, Gong Y, Handberg E, Gulati M, Bairey Merz CN, Pepine CJ, Cooper-DeHoff RM. Mortality risk associated with resistant hypertension among women: analysis from three prospective cohorts encompassing the spectrum of women’s heart disease. J Womens Health (Larchmt). 2016 May 25. PubMed
  • Rutledge T, Kenkre TS, Thompson DV, Bittner VA, Whittaker K, Eastwood J-A, Eteiba W, Cornell CE, Krantz DS, Pepine CJ, Johnson BD, Handberg EM, Bairey Merz CN. Psychosocial predictors of long-term mortality among women with suspected myocardial ischemia: the NHLBI-sponsored Women’s Ischemia Syndrome Evaluation. J Behav Med. 2016 Mar 26. PubMed
  • Bairey Merz CN, Handberg EM, Shufelt CL, Mehta PK, Minissian MB, Wei J, Thomson LE, Berman DS, Shaw LJ, Petersen JW, Brown GH, Anderson RD, Shuster JJ, Cook-Wiens G, Rogatko A, Pepine CJ. A randomized, placebo-controlled trial of late Na current inhibition (ranolazine) in coronary microvascular dysfunction (CMD): impact on angina and myocardial perfusion reserve. Eur Heart J. 2016;37:1504-13. PubMed
  • Khaliq A, Johnson BD, Anderson RD, Bavry AA, Cooper-DeHoff RM, Handberg EM, Bairey Merz CN, Nicholls SJ, Nissen S, Pepine CJ. Relationships between components of metabolic syndrome and coronary intravascular ultrasound atherosclerosis measures in women without obstructive coronary artery disease: the NHLBI-sponsored Women’s Ischemia Syndrome Evaluation (WISE) study. Cardiovasc Endocrinol. 2015;4:45-52. PubMed Central
  • Brush JE Jr, Handberg EM, Biga C, Birtcher KK, Bove AA, Casale PN, Clark MG, Garson A Jr, Hines JL, Linderbaum JA, Rodgers GP, Shor RA, Thourani VH, Wyman JF. 2015 ACC Health Policy Statement on Cardiovascular Team-Based Care and the Role of Advanced Practice Providers. J Am Coll Cardiol. 2015;65(19):2118-36. PubMed
  • Haftbaradaran A, Zaya M, Mehta PK, Shufelt C, Lentz G, Dhawan S, Petersen J, Handberg E, Johnson BD, Pepine CJ, Leach D, Long S, Merz C. Five-year stroke rate in women with signs and symptoms of ischemia undergoing coronary angiography: a retrospective study from the NHLBI-sponsored Women’s Ischemia Syndrome Evaluation (WISE). JRSM Open. 2015 Mar 18;6(3):2054270415577761. doi: 10.1177/2054270415577761. eCollection 2015 Mar. PubMed Central
  • Mohandas R, Segal MS, Huo T, Handberg EM, Petersen JW, Johnson BD, Sopko G, Bairey Merz CN, Pepine CJ. Renal function and coronary microvascular dysfunction in women with symptoms/signs of ischemia. PLoS One. 2015 May 7;10(5):e0125374. PubMed Central
  • Denardo SJ, Gong Y, Cooper-DeHoff RM, Farsang C, Keltai M, Szirmai L, Messerli FH, Bavry AA, Handberg EM, Mancia G, Pepine CJ. Effects of verapamil SR and atenolol on 24-Hour blood pressure and heart rate in hypertension patients with coronary artery disease: an International Verapamil SR-Trandolapril ambulatory monitoring substudy. PLoS One. 2015 Apr 2;10(4):e0122726. PubMed Central
  • Thomson LE, Wei J, Agarwal M, Haft-Baradaran A, Shufelt C, Mehta PK, Gill E, Johnson BD, Kenkre T, Handberg E, Li D, Sharaf B, Berman DS, Petersen J, Pepine CJ, Bairey Merz CN. Cardiac magnetic resonance myocardial perfusion reserve index is reduced in women with coronary microvascular dysfunction: a National Heart, Lung and Blood Institute-sponsored study from the Women’s Ischemia Syndrome Evaluation (WISE). Circ Cardiovasc Imaging. 2015;8(4). pii: e002481. doi: 10.1161/CIRCIMAGING.114.002481 PubMed
  • Mohandas R, Segal M, Srinivas TR, Johnson BD, Wen X, Handberg EM, Petersen JW, Sopko G, Bairey Merz CN, Pepine CJ. Mild renal dysfunction and long-term adverse outcomes in women with chest pain: results from the NHLBI-sponsored Women’s Ischemia Syndrome Evaluation (WISE). Am Heart J. 2015;169(3):412-8. PubMed
  • Bavry AA, Gong Y, Handberg E, Cooper-DeHoff RM, Pepine CJ. Impact of aspirin according to type of stable coronary artery disease: insights from a large international cohort. Am J Med. 2015;128:137-43. PubMed
  • Olson RE, Vojvodic RW, Bettencourt JW, Handberg EM, Szymanski B, Smith D, LaRock J, Sharma SV, Taylor DA, Henry TD; Cardiovascular Cell Therapy Research Network (CCTRN). Recruiting for acute myocardial infarction cell therapy trials: challenges and best practices. Clin Res (Alex). 2014;28(4):71-7. PubMed Central
  • Bavry AA, Handberg EM, Huo T, Lerman A, Quyyumi AA, Shufelt C, Sharaf B, Bairey Merz CN, Cooper-DeHoff RM, Sopko G, Pepine CJ. Aldosterone inhibition and coronary endothelial function in women without obstructive coronary artery disease: an ancillary study of the National Heart, Lung andBlood Institute-sponsored Women’s Ischemia Syndrome Evaluation. Am Heart J. 2014;167:826-32. PubMed Central
  • Petersen JW, Johnson BD, Kip KE, Anderson RD, Handberg EM, Sharaf B, Mehta PK, Kelsey SF, Bairey Merz CN, Pepine CJ. TIMI frame count and adverse events in women with no obstructive coronary disease: a pilot study from the NHLBI-sponsored Women’s Ischemia Syndrome Evaluation (WISE). PloS One. 2014;9(5):e96630. PubMed Central
  • Rutledge T, Kenkre TS, Thompson DV, Bittner VA, Whittaker K, Eastwood J-A, Eteiba W, Cornell CE, Krantz DS, Pepine CJ, Johnson BD, Handberg EM, Bairey Merz CN. Depression, dietary habits, and cardiovascular events among women with suspected myocardial ischemia. Am J Med. 2014; pii:S0002-9343(14)00348-9. PubMed Central
  • Petersen JW, Mehta PK, Kenkre TS, Anderson RD, Johnson BD, Shufelt C, Samuels B, Kar S, Azarbal B, Handberg E, Kothawade K, Pepine CJ, Bairey Merz CN. Comparison of low and high dose intracoronary adenosine and acetylcholine in women undergoing coronary reactivity testing: results from the NHLBI-sponsored Women’s Ischemia Syndrome Evaluation (WISE). Int J Cardiol. 2014;172(1):e114-5. PubMed
  • Smith SM, Gong Y, Handberg EM, Messerli FH, Bakris GL, Ahmed A, Bavry AA, Pepine CJ, Cooper-DeHoff RM. Predictors and outcomes of resistant hypertension among patients with coronary artery disease and hypertension. J Hypertens. 2014;32(3):635-43. PubMed
  • Mohandas R, Sautina L, Li S, Wen X, Huo T, Handberg E, Chi Y-Y, Bairey Merz CN, Pepine CJ, Segal MS. Number and function of bone-marrow derived angiogenic cells and coronary flow reserve in women without obstructive coronary artery disease: a substudy of the NHLBI-sponsored Women’s Ischemia Syndrome Evaluation (WISE). PLoS ONE. 2013;8(12):e81595. PubMed Central

Additional Publications

Please click here for a list of Dr. Handberg’s industry relationships.