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Carl J. Pepine, MD

Carl J. Pepine, MD, MACC
Professor of Medicine


TEL: (352) 265-0820
CLINIC FAX: (352) 627-4293
ADMIN: (352) 273-9065



Carl J. Pepine, MD, is Professor of Medicine, Division of Cardiovascular Medicine at the University of Florida College of Medicine in Gainesville, Florida. He is Division Director Emeritus and Eminent Scholar Emeritus.




BS University of Pittsburgh Pre-Medical
MD New Jersey Medical School
Residency Jefferson Medical College Hospital
Regional Naval Medical Center
Internal Medicine
Fellowship Regional Naval Medical Center and Jefferson Medical College Hospital Cardiopulmonary Physiology and Cardiovascular Medicine

Academic/Research Interests:

Dr. Pepine is an internationally recognized leader in both the clinical and scientific areas of cardiovascular medicine. His major interests focus on the pathophysiology of ischemic heart disease and coronary and systemic vascular hemodynamic mechanisms underlying the disease. He is principal investigator for the UF center for the NHLBI-funded Women’s Ischemia Syndrome Evaluation (WISE) and the UF center for the Cardiovascular Cell Therapy Research Network (CCTRN). He has been or is the PI for many investigator initiated clinical trials, as well as NHLBI trials. He is past president of the American College of Cardiology (ACC), the national professional organization for cardiovascular specialists. He currently serves on the Board of Trustees of the ACC and many committees and task forces and is the founder and overall Project Chair for the Vascular Biology Working Group (VBWG).

Clinical Interests:

  • Ischemic Heart Disease
  • Heart Disease in Women
  • Coronary Microvascular Disease
  • High Blood Pressure (Hypertension)
  • Ischemic Cardiomyopathy
  • Stem Cell Research
  • Supraventricular Tachycardia (SVT)
  • Subcutaneous ICD Implantation

Recent Publications:

  • Gong Y, McDonough CW, Beitelshees AL, El Rouby N, Hiltunen TP, O’Connell JR, Padmanabhan S, Langaee TY, Schmidt SO, Curry RW Jr, Gums JG, Donner KM, Kontula KK, Bailey KR, Boerwinkle E, Takahashi A, Tanaka T, Kubo M, Chapman AB, Turner ST, Pepine CJ, Cooper-DeHoff RM, Johnson JA. PTPRD gene associated with blood pressure response to atenolol and resistant hypertension. J Hypertens. 2015;33(11):2278-85.
  • Anderson RD, Pepine CJ. The coronary microcirculation in STEMI: The next frontier? Eur Heart J. doi: 10.1093/eurheartj/ehv495.
  • Qi Y, Aranda JM, Rodriguez V, Raizada MK, Pepine CJ. Impact of antibiotics on arterial blood pressure in a patient with resistant hypertension—a case report. Int J Cardiol. 2015 Jul 30;201:157-8.
  • Khaliq A, Johnson BD, Anderson RD, Bavry AA, Cooper-DeHoff RM, Handberg EM, Bairey Merz CN, Nicholls SJ, Nissen S, Pepine CJ. Relationships between components of metabolic syndrome and coronary intravascular ultrasound atherosclerosis measures in women without obstructive coronary artery disease: the NHLBI-sponsored Women’s Ischemia Syndrome Evaluation (WISE) study. Cardiovasc Endocrinol. 2015;4:45-52.
  • Park K, Wei J, Minissian M, Bairey Merz CN, Pepine CJ. Adverse pregnancy conditions, infertility, and future cardiovascular risk: implications for mother and child. Cardiovasc Drugs Ther. 2015;29(4):391-402.
  • Mohandas R, Anderson RD, Pepine CJ. Acute kidney injury after transcatheter aortic valve replacement. Am J Nephrol. 2015;41:370-1.
  • Mohandas R, Segal MS, Huo T, Handberg EM, Petersen JW, Johnson BD, Sopko G, Bairey Merz CN, Pepine CJ. Renal function and coronary microvascular dysfunction in women with symptoms/signs of ischemia. PLoS One. 2015 May 7;10(5):e0125374.
  • Shufelt C, Braunstein GD, Pepine CJ, Bairey Merz CN. Recognizing sex similarities in cardiovascular disease research. J Am Coll Cardiol. 2015;65(19):2152-3.
  • Yang T, Santisteban MM, Rodriguez V, Li E, Ahmari N, Marulanda J, Zadeh M, Gong M, Qi Y, Zubcevic J, Sahay B, Pepine CJ, Raizada MK, Mohamadzadeh M. Gut microbiota dysbiosis is linked to hypertension. Hypertension. 2015;65(6):1331-40.
  • Denardo SJ, Gong Y, Cooper-DeHoff RM, Farsang C, Keltai M, Szirmai L, Messerli FH, Bavry AA, Handberg EM, Mancia G, Pepine CJ. Effects of verapamil SR and atenolol on 24-Hour blood pressure and heart rate in hypertension patients with coronary artery disease: an International Verapamil SR-Trandolapril ambulatory monitoring substudy. PLOS ONE. 2015 Apr 2;10(4):e0122726.
  • Pepine CJ. Multiple causes for ischemia without obstructive coronary artery disease: Not a short list! Circulation. 2015;131(12):1044-6.
  • Haftbaradaran A, Zaya M, Mehta PK, Shufelt C, Lentz G, Dhawan S, Petersen J, Handberg E, Johnson BD, Pepine CJ, Leach D, Long S, Merz C. Five-year stroke rate in women with signs and symptoms of ischemia undergoing coronary angiography: a retrospective study from the NHLBI-sponsored Women’s Ischemia Syndrome Evaluation (WISE). JRSM Open. 2015 Mar 18;6(3):2054270415577761. doi: 10.1177/2054270415577761. eCollection 2015 Mar.
  • Thomson LE, Wei J, Agarwal M, Haft-Baradaran A, Shufelt C, Mehta PK, Gill E, Johnson BD, Kenkre T, Handberg E, Li D, Sharaf B, Berman DS, Petersen J, Pepine CJ, Bairey Merz CN. Cardiac magnetic resonance myocardial perfusion reserve index is reduced in women with coronary microvascular dysfunction: a National Heart, Lung, and Blood Institute-sponsored study from the Women’s Ischemia Syndrome Evaluation (WISE). Circ Cardiovasc Imaging. 2015;8(4). pii: e002481. doi: 10.1161/CIRCIMAGING.114.002481
  • Mohandas R, Segal M, Srinivas TR, Johnson BD, Wen X, Handberg EM, Petersen JW, Sopko G, Bairey Merz CN, Pepine CJ. Mild renal dysfunction and long-term adverse outcomes in women with chest pain: results from the National Heart, Lung and Blood Institute-sponsored Women’s Ischemia Syndrome Evaluation (WISE). Am Heart J. 2015;169(3):412-8.
  • Schutt RC, Trachtenberg BH, Cooke JP, Traverse JH, Henry TD, Pepine CJ, Willerson JT, Perin EC, Ellis SG, Zhao D, Bhatnagar A, Johnstone BH, Lai D, Resende M, Ebert RF, Wu JC, Sayre SL, Orozco A, Zierold C, Simari RD, Moye L, Cogle CR, Taylor DA. Bone marrow characteristics associated with changes in infarct size after STEMI: a biorepository evaluation from the CCTRN TIME trial. Circ Res. 2015;116(1):99-107.
  • Park KE, Pepine CJ. Assessing cardiovascular risk in women—looking beyond traditional risk factors. Trends Cardiovasc Med. 2014 Nov 4. pii: S1050-1738(14)00202-3. [Epub ahead of print]
  • Fontana V, McDonough CW, Gong Y, El Rouby NM, Sá ACC, Taylor KD, Chen Y-D I, Gums JG, Chapman AB, Turner ST, Pepine CJ, Johnson JA, Cooper-DeHoff RM. Large-scale gene-centric analysis identifies polymorphisms for resistant hypertension. J Am Heart Assoc. 2014;3(6):e001398.
  • Petersen JW, Winchester DE, Park K, Szady AD, Della Rocca DG, Ahmed M, Tassin H, Qi Y, Pepine CJ. A training program in cardiovascular cell-based therapy: from the NHLBI Cardiovascular Cell Therapy Research Network. Regen Med. 2014;9(6):793-7.
  • Elgendy IY, Huo T, Chik V, Pepine CJ, Bavry AA. Efficacy and safety of angiotensin receptor blockers in older patients: a meta-analysis of randomized trials. Am J Hypertens. 2014 Nov 11. pii: hpu209 [Epub ahead of print]
  • Petersen JW, Pepine CJ. Microvascular coronary dysfunction and ischemic heart disease—Where are we in 2014? Trends Cardiovasc Med. pii: S1050-1738(14)00168-6. [Epub ahead of print]
  • Bavry AA, Gong Y, Handberg E, Cooper-DeHoff RM, Pepine CJ. Impact of aspirin according to type of stable coronary artery disease: insights from a large international cohort. Am J Med. 2014 Oct 15. pii: S0002-9343(14)00907-3. [Epub ahead of print]
  • Winchester DE, Pepine CJ. Usefulness of beta blockade in contemporary management of patients with stable coronary heart disease. Am J Cardiol. 2014;114(10):1607-12.
  • Cogle CR, Wise E, Meacham AM, Zierold C, Traverse JH, Henry TD, Perin EC, Willerson JT, Ellis SG, Carlson MA, Zhao D, Bolli R, Cooke JP, Anwaruddin S, Bhatnagar A, Cabreira-Graca M, Grant MB, Lai D, Moyé L, Ebert RF, Olson RE, Sayre SL, Schulman IH, Bosse RC, Scott EW, Simari RD, Pepine CJ, Taylor D. A detailed analysis of bone marrow from patients with ischemic heart disease and left ventricular dysfunction: BM CD34, CD11b, and clonogenic capacity as biomarkers for clinical outcomes. Circ Res. 2014;115:867-74.
  • O’Donoghue ML, Braunwald E, White HD, Steen DP, Lukas MA, Tarka E, Steg PG, Hochman JS, Bode C, Maggioni AP, Im K, Shannon JB, Davies RY, Murphy SA, Crugnale SE, Wiviott SD, Bonaca MP, Watson DF, Weaver WD, Serruys PW, Cannon CP; SOLID-TIMI 52 Investigators [Pepine CJ]. Effect of darapladib on major coronary events after an acute coronary syndrome: the SOLID-TIMI 52 randomized clinical trial. JAMA. 2014;312(10):1006-15.
  • Sundström J, Arima H, Woodward M, Jackson R, Karmali K, Lloyd-Jones D, Baigent C, Emberson J, Rahimi K, MacMahon S, Patel A, Perkovic V, Turnbull F, Neal B; for the Blood Pressure Lowering Treatment Trialists’ Collaboration [Pepine CJ]. Blood pressure-lowering treatment based on cardiovascular risk: a meta-analysis of individual patient data. Lancet. 2014;384(9943):591-8.
  • Krakoff L, Gillespie RL, Ferdinand K, Fergus I, Akinboboye O, Williams K, Walsh M, Bairey Merz CN, Pepine CJ. 2014 hypertension recommendations from JNC 8 panel members raise concerns for elderly black and female populations. J Am Coll Cardiol. 2014;64(4):394-402.
  • Bangalore S, Gong Y, Cooper-DeHoff RM, Pepine CJ, Messerli F. 2014 Eighth Joint National Committee Panel recommendation for blood pressure targets revisited: results from the INVEST study. J Am Coll Cardiol. 2014;64(8):784-93.
  • Pahor M, Guralnik JM, Ambrosius WT, Blair S, Bonds DE, Church TS, Espeland MA, Fielding RA, Gill TM, Groessl EJ, King AC, Kritchevsky SB, Manini TM, McDermott MM, Miller ME, Newman AB, Rejeski WJ, Sink KM, Williamson JD; LIFE study investigators [Pepine CJ]. Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial. JAMA. 2014;311(23):2387-96.
  • Petersen JW, Pepine CJ. The prevalence of microvascular dysfunction, its role among men, and links with adverse outcomes: Non-invasive imaging reveals the tip of the iceburg. Circulation. 2014;129:2497-9.
  • Pepine CJ. Update in Cardiology: Evidence Published in 2013. Ann Intern Med. 2014;160:847-52.
  • Vemulapalli S, Ard J, Bakris GL, Bhatt DL, Brown AS, Cushman WC, Ferdinand KC, Flack JM, Fleg JL, Katzen BT, Kostis JB, Oparil S, Patel CB, Pepine CJ, Piña IL, Rocha-Singh KJ, Townsend RR, Peterson ED, Califf RM, Patel MR. Proceedings from Duke Resistant Hypertension Think Tank. Am Heart J. 2014;167:775-8.
  • Bavry AA, Handberg EM, Huo T, Lerman A, Quyyumi AA, Shufelt C, Sharaf B, Bairey Merz CN, Cooper-DeHoff RM, Sopko G, Pepine CJ. Aldosterone inhibition and coronary endothelial function in women without obstructive coronary artery disease: an ancillary study of the National Heart, Lung and Blood Institute-sponsored Women’s Ischemia Syndrome Evaluation. Am Heart J. 2014;167:826-32.
  • Petersen JW, Johnson BD, Kip KE, Anderson RD, Handberg EM, Sharaf B, Mehta PK, Kelsey SF, Merz CN, Pepine CJ. TIMI frame count and adverse events in women with no obstructive coronary disease: a pilot study from the NHLBI-sponsored Women’s Ischemia Syndrome Evaluation (WISE). PloS One. 2014;9(5):e96630.
  • White HD, Held C, Stewart R, et al., STABILITY Investigators [Pepine CJ]. Darapladib for preventing ischemic events in stable coronary heart disease. N Engl J Med. 2014;370(18):1702-11.
  • Rutledge T, Kenkre TS, Thompson DV, Bittner VA, Whittaker K, Eastwood J-A, Eteiba W, Cornell CE, Krantz DS, Pepine CJ, Johnson BD, Handberg EM, Bairey Merz CN. Depression, dietary habits, and cardiovascular events among women with suspected myocardial ischemia. Am J Med. 2014;pii:S0002-9343(14)00348-9.
  • Pepine CJ, Petersen JW, Bairey Merz CN. A microvascular-myocardial diastolic dysfunctional state and risk for mental stress ischemia: a revised concept of ischemia during daily life. JACC Cardiovascular Imaging. 2014;7(4):362-5.
  • Vaz Fragoso CA, Miller ME, Fielding RA, King AC, Kritchevsky SB, McDermott MM, Myers V, Newman AB, Pahor M, Gill TM; Lifestyle Interventions and Independence in Elder Study Group [Pepine CJ]. Sleep-wake disturbances in sedentary community-dwelling elderly adults with functional limitations. J Am Geriatr Soc. 2014;62(6):1064-72.
  • Vaz Fragoso CA, Beavers DP, Hankinson JL, Flynn G, Berra K, Kritchevsky SB, Liu CK, McDermott MM, Manini TM, Rejeski WJ, Gill TM; Lifestyle Interventions Independence for Elders Study Investigators [Pepine CJ]. Respiratory impairment and dyspnea and their associations with physical inactivity and mobility in sedentary community-dwelling older persons. J Am Geriatr Soc. 2014 Apr;62(4):622-8.
  • Simari RD, Pepine CJ, Traverse JH, Henry TD, Bolli R, Spoon D, Yeh E, Hare JM, Schulman IH, Anderson RD, Lambert C, Sayre SL, Taylor DA, Ebert RF, Moyé LA. Bone marrow mononuclear cell therapy for acute myocardial infarction: a perspective from the Cardiovascular Cell Therapy Research Network. Circ Res. 2014;114(10):1564-8.
  • Traverse JH, Henry TD, Pepine CJ, Willerson JT, Ellis SG. One-year follow-up of intracoronary stem cell delivery on left ventricular function following ST-elevation myocardial infarction (Research Letter). JAMA. 2014;311(3):301-2.
  • Smith SM, Huo T, Johnson BD, Bittner V, Kelsey S, Thompson DV, Bairey Merz CN, Pepine CJ, Cooper-DeHoff RM. Cardiovascular and mortality risk of apparent resistant hypertension in women with suspected myocardial ischemia: a report from the NHLBI-sponsored WISE study. JAHA. 2014;3(1):e000660.
  • Smith SM, Pepine CJ, Cooper-DeHoff RM. Reply to ‘Resistant hypertension revisited: definition and true prevalence’. J Hypertens. 2014;32(7):1547.
  • Smith SM, Gong Y, Handberg EM, Messerli FH, Bakris GL, Ahmed A, Bavry AA, Pepine CJ, Cooper-DeHoff RM. Predictors and outcomes of resistant hypertension among patients with coronary artery disease and hypertension. J Hypertens. 2014;32(3):635-43.
  • Petersen JW, Mehta PK, Kenkre TS, Anderson RD, Johnson BD, Shufelt C, Samuels B, Kar S, Azarbal B, Handberg E, Kothawade K, Pepine CJ, Bairey Merz CN. Comparison of low and high dose intracoronary adenosine and acetylcholine in women undergoing coronary reactivity testing: results from the NHLBI-sponsored Women’s Ischemia Syndrome Evaluation (WISE). Int J Cardiol. 2014;172(1):e114-5.

Additional Publications

Please click here for a list of Dr. Pepine’s industry relationships.