Yejia Song, MD
- Dr. Song’s major research field is cardiac cellular electrophysiology. Specifically, he is interested in the adrenergic, muscarinic and purinergic receptor-mediated regulation of cardiac membrane potentials and currents and in the ionic mechanisms underlying cardiac arrhythmic activities. His studies are conducted on single atrial and ventricular myocytes, using current- and voltage-clamp techniques. Recently, his study has been focusing on the role of persistent sodium current in abnormal automaticity and triggered activity of cardiac myocytes. The goals of this study are to determine the contribution of persistent sodium current to ectopic activity and to evaluate the potential anti-arrhythmic value of blocking this current. In addition, he is also interested in the regulation of contractile function of single cardiac myocytes. Dr. Song welcomes research collaborations with clinical physicians and basic scientists.
- Cardiac Cellular Electrophysiology
- Hoyer K, Song Y, Wang D, Phan D, Balschi J, Ingwall JS, Belardinelli L, Shryock JC. Reducing the late sodium current improves cardiac function during sodium pump inhibition by ouabain. J Pharmacol Exp Ther. 2011;337:513-23.
- Song Y, Shryock JC, Belardinelli L. A slowly inactivating sodium current contributes to spontaneous diastolic depolarization of atrial myocytes. Am J Physiol Heart Circ Physiol. 2009 Oct;297(4):H1254-62.
- Wu Y, Song Y, Belardinelli L, Shryock JC. The late Na+ current (INa) inhibitor ranolazine attenuates effects of palmitoyl-L-carnitine to increase late INa and cause ventricular diastolic dysfunction. J Pharmacol Exp Ther. 2009 Aug;330(2):550-7.
Please click here for a list of Dr. Song’s industry relationships.