Chelsey S. Simmons, PhD
Affiliate Faculty, J. Crayton Pruitt Family Department of Biomedical Engineering
Courtesy Appointment, Division of Cardiovascular Medicine, Department of Medicine
Dr. Simmons joined the University of Florida Mechanical and Aerospace Engineering faculty in the Fall of 2013, following a visiting research position at the Swiss Federal Institute of Technology (ETH) Zurich. She is the Director of the Biomimetic Actuators and Integrated Technologies (GatorBAIT) Lab, where researchers develop microsystems to mimic bodily functions in a dish. She also serves on the advisory board of a company based on one of her pending patents. Dr. Simmons is a Gainesville native, and enjoys Gator sports, tennis, and triathlon training.
|BS||Harvard University||Engineering Sciences (Mechanical Engineering)|
|MS||Stanford University||Mechanical Engineering|
|PhD||Stanford University||Mechanical Engineering|
Dr. Simmons’ overarching research interests lie in improving the relevance of in vitro systems for clinical applications. Dr. Simmons has developed a novel tool to assess contractility of stem cell-derived cardiomyocytes in culture, enabling a wide range of translational investigations. The GatorBAIT Lab has also developed cell culture systems that mimic cardiovascular tissues in vitro. Specifically, myocardium-like constructs can be made out of co-cultured cells from a variety of sources and mechanically stimulated in high-throughput bioreactors. Dr. Simmons and her team welcome collaborations with clinical and basic science researchers, and the GatorBAIT Lab is always recruiting fun, creative, and hard-working students and postdocs.
- Spearman BS, Agrawal NK, Rubiano A, Simmons CS, Mobini S, Schmidt CE. Tunable methacrylated hyaluronic acid-based hydrogels as scaffolds for soft tissue engineering applications. J Biomed Mater Res A. 2020 Feb;108(2):279-291. doi: 10.1002/jbm.a.36814.
- Nakayama KH, Quarta M, Paine P, Alcazar C, Karakikes I, Garcia V, Abilez OJ, Calvo NS, Simmons CS, Rando TA, Huang NF. Treatment of volumetric muscle loss in mice using nanofibrillar scaffolds enhances vascular organization and integration. Commun Biol. 2019 May 7;2:170. doi: 10.1038/s42003-019-0416-4.
- Rubiano A, Galitz C, Simmons CS. Mechanical Characterization by Mesoscale Indentation: Advantages and Pitfalls for Tissue and Scaffolds. Tissue Eng Part C Methods. 2019 Oct;25(10):619-629. doi: 10.1089/ten.TEC.2018.0372.
- Stewart DC, Serrano PN, Rubiano A, Yokosawa R, Sandler J, Mukhtar M, Brant JO, Maden M, Simmons CS. Unique behavior of dermal cells from regenerative mammal, the African Spiny Mouse, in response to substrate stiffness. J Biomech. 2018 Nov 16;81:149-154. doi: 10.1016/j.jbiomech.2018.10.005.
- Rubiano A, Delitto D, Han S, Gerber M, Galitz C, Trevino J, Thomas RM, Hughes SJ, Simmons CS. Viscoelastic properties of human pancreatic tumors and in vitro constructs to mimic mechanical properties. Acta Biomater. 2018;67:331-40.
- Stewart DC, Rubiano A, Dyson K, Simmons CS. Mechanical characterization of human brain tumors from patients and comparison to potential surgical phantoms. PLoS One. 2017;12(6):e0177561.
- Santisteban MM, Qi Y, Zubcevic J, Kim S, Yang T, Shenoy V, Cole-Jeffrey CT, Lobaton GO, Stewart DC, Rubiano A, Simmons CS, Garcia-Pereira F, Johnson RD, Pepine CJ, Raizada MK. Hypertension-linked pathophysiological alterations in the gut. Circ Res. 2017;120(2):312-23.
- Stewart DC, Rubiano A, Santisteban MM, Shenoy V, Qi Y, Pepine CJ, Raizada MK, Simmons CS. Hypertension-linked mechanical changes of rat gut. Acta Biomater. 2016;45:296-302.
- Rocca DG, Willenberg BJ, Qi Y, Simmons CS, Rubiano A, Ferreira LF, Huo T, Petersen JW, Ruchaya PJ, Wate PS, Wise EA, Handberg EM, Cogle CR, Batich CD, Byrne BJ, Pepine CJ. An injectable capillary-like microstructured alginate hydrogel improves left ventricular function after myocardial infarction in rats. Int J Cardiol. 2016;220:149-54.
- Fang X, Poulsen RR, Wang-Hu J, Shi O, Calvo NS, Simmons CS, Rivkees SA, Wendler CC. Knockdown of DNA methyltransferase 3a alters gene expression and inhibits function of embryonic cardiomyocytes. FASEB J. 2016;30(9):3238-55.
- Rubiano A, Qi Y, Guzzo D, Rathinasabapathy A, Rowe K, Pepine C, Simmons C. Stem cell therapy restores viscoelastic properties of myocardium in rat model of hypertension. J Mech Behav Biomed Mater. 2016;59:71-7.
- Biel NM, Santostefano KE, DiVita BB, El Rouby N, Carrasquilla SD, Simmons C, Nakanishi M, Cooper-DeHoff RM, Johnson JA, Terada N. Vascular smooth muscle cells from hypertensive patient-derived induced pluripotent stem cells to advance hypertension pharmacogenomics. Stem Cells Transl Med. 2015;4(12):1380-90.
- Bai F, Ho Lim C, Jia J, Santostefano K, Simmons C, Kasahara H, Wu W, Terada N, Jin S. Directed differentiation of embryonic stem cells into cardiomyocytes by bacterial injection of defined transcription factors. Sci Rep. 2015;5:15014.
- Burridge PW, Metzler SA, Nakayama KH, Abilez OJ, Simmons CS, Bruce MA, Matsuura Y, Kim P, Wu JC, Butte M, Huang NF, Yang PC. Multi-cellular interactions sustain long-term contractility of human pluripotent stem cell-derived cardiomyocytes. Am J Transl Res. 2014;6(6):724-35.
Please click here for a list of Dr. Simmons’ industry relationships.