Katelyn A Bruno, PhD, FHFSA, FACC
Assistant Professor Of Cardiovascular Medicine
About Katelyn A Bruno
Dr. Katelyn Bruno is an Assistant Professor of Cardiovascular Medicine in the Department of Medicine/Division of Cardiovascular Medicine with joint appointments in the Department of Physiology and Aging and the Center of Regenerative Medicine. She received her Ph.D. in Environmental Health Sciences with a focus on Molecular and Translational Toxicology from Johns Hopkins Bloomberg School of Public Health in 2016 and completed her Postdoctoral Fellowship at Mayo Clinic in Jacksonville, Florida. Her broad focus includes translational science, cardiology, immunology, toxicology and sex differences. Dr. Bruno is actively involved in organizational and scientific organizations including serving as faculty advisor for the UF RegeneGators student organization and holding committee and leadership roles for societies such as HFSA, FCACC, OSSD and ISCMF.
Additional Positions:
Research Collaborator
2022 – Current
·
Mayo Clinic
Courtesy Research Faculty
2020 – Current
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University of North Florida
Related Links:
Accomplishments
Fellow, American College of Cardiology (FACC)
2024
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American College of Cardiology
Outstanding Young Alumni
2024
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Sam Houston State University
Fellow, Heart Failure Society of America (FHFSA)
2022
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Heart Failure Society of America
Special Achievement Award
2022
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Florida Chapter of the American College of Cardiology
2020 Outstanding Quality Improvement Project, Gold Zebra EDS Clinic
2021
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Mayo Clinic
Selected Menttee
2021
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European Society of Cardiology Heart Failure Association Translational Winter Meeting
Team Science Award Recognition
2021
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Mayo Clinic
Biology of Sex Differences Journal Selection of Best Poster Prize Finalist
2019
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Organization for the Study of Sex Differences Meeting
Future Leader in Heart Failure Designation
2019
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Heart Failure Society of America
Heart Failure Specialists of Tomorrow (HOT) Travel Award
2019
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Heart Failure Association of the European Society of Cardiology
Travel Award to Heart Failure Association of the European Society of Cardiology Meeting, Athens, Greece
2019
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Heart Failure Association of the European Society of Cardioloy
Young Investigator of the Year Award: Basic and Translational Science
2019
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Heart Failure 2019 & World Congress on Acute Heart Failure, Heart Failure Association of the European Society of Cardiology
Above & Beyond Certificate of Excellence
2018
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Mayo Clinic
Environmental Scholar
2018
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American Pediatric Association (APA)
Heart Failure Specialists of Tomorrow (HOT) Travel Award
2018
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Heart Failure Association of the European Society of Cardiology
New Investigator Travel Award
2018
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American Heart Association: Basic Cardiovascular Sciences Scientific Sessions (BCVS)
The Jay N. Cohn New Investigator Award Runner-Up
2018
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Heart Failure Society of America
Young Investigator Award
2016
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Mayo Clinic Angiogenesis and Tumor Microenvironment Symposium
Poster Award
2014
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American Association of Immunologist Annual Meeting
1st Place Poster Presentation
2013
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What a Difference an X Makes Conference hosted by Society of Women’s Health Research
Teaching Profile
Courses Taught
2023-2024
IDH3931 Interdisciplinary Junior Honors
Research Profile
Dr. Bruno’s graduate research focused on the mechanisms of hormones and endocrine disruptors in myocarditis (inflammatory heart disease). Dr. Bruno continued studying myocarditis during her postdoctoral fellowship focusing on new diagnostics (biomarkers and imaging) and therapeutics for acute myocarditis and dilated cardiomyopathy. Dr. Bruno is experienced in basic and translational research working with cell culture, animals and patients samples. In addition to her role as a NIAID funded tenure track Assistant Professor studying novel models and mechanisms of both pediatric and adult myocarditis, Dr. Bruno is also Co-Investigator on several internally funded grants and a DoD grant. Dr. Bruno has volunteer roles in several healthcare based non-profits in order to personally connect with the people who are affected by myocarditis and is involved in leadership for several scientific organizations.
Open Researcher and Contributor ID (ORCID)
0000-0001-8980-6059
Areas of Interest
- Age Differences
- Cardio-Oncology
- Dilated Cardiomyopathy
- Heart Failure
- Myocarditis
- Sex Differences
- hypermobile Ehlers-Danlos Syndrome (hEDS)
Publications
2024
A Possible Newly Defined and Treatable Secondary Cause of Early Morning Wake-Up Headaches in an Older Hypermobile Woman: Nutcracker Physiology with Spinal Epidural Venous Congestion.
Case reports in neurology.
16(1):71-78
[DOI] 10.1159/000537705.
[PMID] 38449705.
2024
Cardiac defects of hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorders: a retrospective cohort study.
Frontiers in cardiovascular medicine.
11
[DOI] 10.3389/fcvm.2024.1332508.
[PMID] 38562189.
2024
Laryngological Complaint Prevalence in Hypermobile Ehlers-Danlos or Hypermobility Spectrum Disorders.
The Laryngoscope.
134(2):773-778
[DOI] 10.1002/lary.30964.
[PMID] 37597175.
2024
Research summary of poster presentations at the 2023 Florida cardio-oncology symposium.
American heart journal plus : cardiology research and practice.
37
[DOI] 10.1016/j.ahjo.2023.100348.
[PMID] 38510509.
2023
Extracellular vesicles as personalized medicine.
Molecular aspects of medicine.
91
[DOI] 10.1016/j.mam.2022.101155.
[PMID] 36456416.
2023
High overlap in patients diagnosed with hypermobile Ehlers-Danlos syndrome or hypermobile spectrum disorders with fibromyalgia and 40 self-reported symptoms and comorbidities.
Frontiers in medicine.
10
[DOI] 10.3389/fmed.2023.1096180.
[PMID] 37181352.
2023
Rates Among Hospitalized Patients With COVID-19 Treated With Convalescent Plasma: A Systematic Review and Meta-Analysis.
Mayo Clinic proceedings. Innovations, quality & outcomes.
7(5):499-513
[DOI] 10.1016/j.mayocpiqo.2023.09.001.
[PMID] 37859995.
2023
Reconstituted Extracellular Vesicles from Human Platelets Decrease Viral Myocarditis in Mice
Small.
19(49)
[DOI] 10.1002/smll.202303317.
[PMID] 37612820.
2023
Sex and gender differences in myocarditis and dilated cardiomyopathy: An update.
Frontiers in cardiovascular medicine.
10
[DOI] 10.3389/fcvm.2023.1129348.
[PMID] 36937911.
2023
Sex differences in left-ventricular strain in a murine model of coxsackievirus B3 myocarditis.
iScience.
26(12)
[DOI] 10.1016/j.isci.2023.108493.
[PMID] 38146431.
2023
Sex differences in mitochondrial gene expression during viral myocarditis.
Research square.
[DOI] 10.21203/rs.3.rs-3716881/v1.
[PMID] 38196574.
2023
The Impact of a Group Telemedicine Program for Chronic Disease: A Retrospective Cohort Survey Study on Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorder
Telemedicine and e-Health.
29(2):261-269
[DOI] 10.1089/tmj.2022.0092.
2022
Cardiovascular Factors Associated with COVID-19 from an International Registry of Primarily Japanese Patients.
Diagnostics (Basel, Switzerland).
12(10)
[DOI] 10.3390/diagnostics12102350.
[PMID] 36292038.
2022
Chapter 9. Autoimmune Heart Disease
Translational Autoimmunity: Autoimmune Diseases in Different Organs, Part IV: Specific Autoimmune Diseases.
2022
Concerns about estimating relative risk of death associated with convalescent plasma for COVID-19
Nature Medicine.
28(1):51-52
[DOI] 10.1038/s41591-021-01638-6.
2022
Establishing an Ehlers-Danlos Syndrome Clinic: Lessons Learned.
SN comprehensive clinical medicine.
4(1)
[DOI] 10.1007/s42399-022-01218-w.
[PMID] 35811641.
2022
Late Treatment for COVID-19 With Convalescent Plasma
CHEST.
162(5):e283-e284
[DOI] 10.1016/j.chest.2022.07.029.
[PMID] 36344142.
2022
Molecular Modeling and Phenotypic Description of a Patient with a Novel Exonic Deletion of GALNS with Resultant Morquio Syndrome with Two Successful Pregnancies
Molecular Syndromology.
13(4):1-8
[DOI] 10.1159/000519326.
[PMID] 36158053.
2022
Myocarditis and Pericarditis
Comprehensive Pharmacology.
413-431
[DOI] 10.1016/b978-0-12-820472-6.00091-8.
2022
Sex and age differences in sST2 in cardiovascular disease.
Frontiers in cardiovascular medicine.
9
[DOI] 10.3389/fcvm.2022.1073814.
[PMID] 36741845.
2022
Sex differences in comorbidities associated with Sjögren’s disease.
Frontiers in medicine.
9
[DOI] 10.3389/fmed.2022.958670.
[PMID] 35991633.
2022
Upregulation of Endothelin-1 May Predict Chemotherapy-Induced Cardiotoxicity in Women with Breast Cancer
Journal of Clinical Medicine.
11(12)
[DOI] 10.3390/jcm11123547.
[PMID] 35743613.
2021
A Novel Circulating MicroRNA for the Detection of Acute Myocarditis.
The New England journal of medicine.
384(21):2014-2027
[DOI] 10.1056/NEJMoa2003608.
[PMID] 34042389.
2021
Access to and safety of COVID-19 convalescent plasma in the United States Expanded Access Program: A national registry study
PLOS Medicine.
18(12)
[DOI] 10.1371/journal.pmed.1003872.
[PMID] 34928960.
2021
Convalescent Plasma Antibody Levels and the Risk of Death from Covid-19.
The New England journal of medicine.
384(11):1015-1027
[DOI] 10.1056/NEJMoa2031893.
[PMID] 33523609.
2021
Convalescent Plasma Therapy for COVID-19: A Graphical Mosaic of the Worldwide Evidence
SSRN Electronic Journal.
[DOI] 10.2139/ssrn.1116056.
2021
Convalescent Plasma Therapy for COVID-19: A Graphical Mosaic of the Worldwide Evidence.
Frontiers in medicine.
8
[DOI] 10.3389/fmed.2021.684151.
[PMID] 34164419.
2021
Mortality in individuals treated with COVID-19 convalescent plasma varies with the geographic provenance of donors
Nature Communications.
12(1)
[DOI] 10.1038/s41467-021-25113-5.
[PMID] 34381030.
2021
Program and patient characteristics for the United States Expanded Access Program to COVID-19 convalescent plasma.
medRxiv : the preprint server for health sciences.
[DOI] 10.1101/2021.04.08.21255115.
[PMID] 33851175.
2021
Sex Differences, Genetic and Environmental Influences on Dilated Cardiomyopathy
Journal of Clinical Medicine.
10(11)
[DOI] 10.3390/jcm10112289.
[PMID] 34070351.
2021
Sex-Specific Effects of Plastic Caging in Murine Viral Myocarditis
International Journal of Molecular Sciences.
22(16)
[DOI] 10.3390/ijms22168834.
[PMID] 34445539.
2021
The Effect of Convalescent Plasma Therapy on COVID-19 Patient Mortality: Systematic Review and Meta-analysis.
medRxiv : the preprint server for health sciences.
[DOI] 10.1101/2020.07.29.20162917.
[PMID] 33140056.
2021
The Effect of Convalescent Plasma Therapy on Mortality Among Patients With COVID-19: Systematic Review and Meta-analysis.
Mayo Clinic proceedings.
96(5):1262-1275
[DOI] 10.1016/j.mayocp.2021.02.008.
[PMID] 33958057.
2021
The Role of Disease Severity and Demographics in the Clinical Course of COVID-19 Patients Treated with Convalescent Plasma.
medRxiv : the preprint server for health sciences.
[DOI] 10.1101/2021.01.19.21249678.
[PMID] 33501470.
2021
The Role of Disease Severity and Demographics in the Clinical Course of COVID-19 Patients Treated With Convalescent Plasma.
Frontiers in medicine.
8
[DOI] 10.3389/fmed.2021.707895.
[PMID] 35155458.
2021
Trpc6 Promotes Doxorubicin-Induced Cardiomyopathy in Male Mice With Pleiotropic Differences Between Males and Females.
Frontiers in cardiovascular medicine.
8
[DOI] 10.3389/fcvm.2021.757784.
[PMID] 35096991.
2021
Use of convalescent plasma in COVID-19 patients with immunosuppression.
Transfusion.
61(8):2503-2511
[DOI] 10.1111/trf.16525.
[PMID] 34036587.
2020
Association of Genetic Variants at TRPC6 With Chemotherapy-Related Heart Failure.
Frontiers in cardiovascular medicine.
7
[DOI] 10.3389/fcvm.2020.00142.
[PMID] 32903434.
2020
Autoimmune Myocarditis: Animal Models
Myocarditis.
111-127
[DOI] 10.1007/978-3-030-35276-9_6.
2020
Early Safety Indicators of COVID-19 Convalescent Plasma in 5,000 Patients.
medRxiv : the preprint server for health sciences.
[DOI] 10.1101/2020.05.12.20099879.
[PMID] 32511566.
2020
Early safety indicators of COVID-19 convalescent plasma in 5000 patients
Journal of Clinical Investigation.
130(9):4791-4797
[DOI] 10.1172/jci140200.
2020
Effect of Convalescent Plasma on Mortality among Hospitalized Patients with COVID-19: Initial Three-Month Experience.
medRxiv : the preprint server for health sciences.
[DOI] 10.1101/2020.08.12.20169359.
[PMID] 32817978.
2020
Examination of Molecular Effects of MYLK Deletion in a Patient with Extensive Aortic, Carotid, and Abdominal Dissections That Underlie the Genetic Dysfunction.
Case reports in medicine.
2020
[DOI] 10.1155/2020/5108052.
[PMID] 32655646.
2020
Myoglobin for Detection of High-Risk Patients with Acute Myocarditis.
Journal of cardiovascular translational research.
13(5):853-863
[DOI] 10.1007/s12265-020-09957-8.
[PMID] 32006209.
2020
Safety Update
Mayo Clinic Proceedings.
95(9):1888-1897
[DOI] 10.1016/j.mayocp.2020.06.028.
[PMID] 32861333.
2020
Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity.
Nature communications.
11(1)
[DOI] 10.1038/s41467-020-15129-8.
[PMID] 32198351.
2019
BPA Alters Estrogen Receptor Expression in the Heart After Viral Infection Activating Cardiac Mast Cells and T Cells Leading to Perimyocarditis and Fibrosis.
Frontiers in endocrinology.
10
[DOI] 10.3389/fendo.2019.00598.
[PMID] 31551929.
2019
Elevated Sera sST2 Is Associated With Heart Failure in Men ≤50 Years Old With Myocarditis.
Journal of the American Heart Association.
8(2)
[DOI] 10.1161/JAHA.118.008968.
[PMID] 30638108.
2018
Sex differences in pulmonary arterial hypertension: role of infection and autoimmunity in the pathogenesis of disease.
Biology of sex differences.
9(1)
[DOI] 10.1186/s13293-018-0176-8.
[PMID] 29669571.
2018
Type 1 sialidosis presenting with ataxia, seizures and myoclonus with no visual involvement.
Molecular genetics and metabolism reports.
15:11-14
[DOI] 10.1016/j.ymgmr.2017.12.005.
[PMID] 30023283.
2017
Genome-wide association study of cardiotoxicity in the NCCTG N9831 (Alliance) adjuvant trastuzumab trial.
Pharmacogenetics and genomics.
27(10):378-385
[DOI] 10.1097/FPC.0000000000000302.
[PMID] 28763429.
2017
Sex Determines Cardiac Myocyte Stretch and Relaxation.
Circulation. Cardiovascular genetics.
10(5)
[DOI] 10.1161/CIRCGENETICS.117.001950.
[PMID] 29030406.
2012
LC-MS/MS analysis of 2-aminothiazoline-4-carboxylic acid as a forensic biomarker for cyanide poisoning.
World journal of methodology.
2(5):33-41
[DOI] 10.5662/wjm.v2.i5.33.
[PMID] 25237615.
2012
Update on coxsackievirus B3 myocarditis.
Current opinion in rheumatology.
24(4):401-7
[DOI] 10.1097/BOR.0b013e328353372d.
[PMID] 22488075.
Grants
Jul 2024
ACTIVE
Elucidating the innate and adaptive immune mechanism differences during viral myocarditis between pediatric and adult populations: role of sex, age and hormone status
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Jul 2023
ACTIVE
Sex differences in novel viral myocarditis therapeutic: adipose-derived stem cell secretome
Role: Principal Investigator
Funding: AMER HEART ASSOCIATION
Jun 2023
ACTIVE
Characterization of TRPC6 to Predict and Prevent Chemotherapy-Related Cardiomyopathy and Heart Failure in Women
Role: Principal Investigator
Funding: MAYO CLINIC
via US ARMY MED RES ACQUISITION
Dec 2022
ACTIVE
Vitamin D binding protein (DBP) in innate immune cell response in viral myocarditis
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Education
Postdoctoral Fellowship
2016-2021
·
Mayo Clinic
Doctor of Philosophy (PhD)
2011-2016
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Johns Hopkins School of Public Health
BS in Chemistry (Minor in Biology)
2010-2011
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Sam Houston State University
BS in Criminal Justice (Minor in Chemistry)
2007-2010
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Sam Houston State University
Contact Details
Phones:
- Business:
- (352) 273-9064
Emails:
- Business:
- katelyn.bruno@ufl.edu
Administrative Spec I:
Addresses:
- Business Street:
-
P.O. Box 100288
Division of Cardiovascular Medicine
GAINESVILLE FL 32611