Eileen M Handberg

Eileen M Handberg, Ph.D., ARNP

PROFESSOR

Department: MD-CARDIOLOGY
Business Phone: (352) 273-8944
Business Email: handbem@medicine.ufl.edu

About Eileen M Handberg

Dr. Handberg is Professor of Medicine and Director of the Cardiovascular Clinical Trials Program in the Division of Cardiovascular Medicine. She is Program Co-Director for the One Florida PCOR.net Clinical Data Research Network. She serves the University as an Institutional Review Board alternate member, serves on the Promotion and Tenure Committee. She is an Adult Nurse Practitioner and works with Interventional Cardiology Service, and manages research patient care. She is program Director for the practitioner competency assessment program Florida CARES, one of only 7 Assessment Centers in the US. She is very active in the American College of Cardiology, serving as the Chair of the Cardiovascular Team Section and several Board level committees. She serves on the Board of Directors for the Preventative Cardiovascular Nurses Association. Her research interests are centered in clinical trial management, Ischemic Heart Disease with a focus on women, stem cell therapy, exercise/prevention, hypertension, and atrial fibrillation.

Board Certifications

  • Adult Nurse Practitioner
    American Nurses Credentialing Center

Clinical Profile

Specialties
  • Medicine
Subspecialties
  • Cardiology
Areas of Interest
  • Healthy living
  • Heart disease
  • Heart disease and women
  • Heart failure – overview

Research Profile

Areas of Interest
  • Exercise & Lifestyle Interventions
  • Heart Disease in Women
  • Heart Failure
  • Ischemic Heart Disease

Publications

2021
Butyrate Regulates COVID-19-Relevant Genes in Gut Epithelial Organoids From Normotensive Rats.
Hypertension (Dallas, Tex. : 1979). 77(2):e13-e16 [DOI] 10.1161/HYPERTENSIONAHA.120.16647. [PMID] 33439735.
2021
Prior Oral Contraceptive Use and Longer Term Mortality Outcomes in Women with Suspected Ischemic Heart Disease.
Journal of women's health (2002). [DOI] 10.1089/jwh.2020.8743. [PMID] 33481672.
2021
Left ventricular circumferential strain and coronary microvascular dysfunction: A report from the Women’s Ischemia Syndrome Evaluation Coronary Vascular Dysfunction (WISE-CVD) Project.
International journal of cardiology. 327:25-30 [DOI] 10.1016/j.ijcard.2020.11.006. [PMID] 33202262.
2021
Preparticipation Cardiac Evaluation Findings in a Cohort of Collegiate Female Athletes.
The American journal of cardiology. 140:134-139 [DOI] 10.1016/j.amjcard.2020.10.055. [PMID] 33144161.
2020
Temporal Trends in Angina, Myocardial Perfusion, and Left Ventricular Remodeling in Women With No Obstructive Coronary Artery Disease Over 1-Year Follow-Up: Results From WISE-CVD.
Journal of the American Heart Association. 9(13) [DOI] 10.1161/JAHA.119.016305. [PMID] 32578481.
2020
Statin Use for Atherosclerotic Cardiovascular Disease Prevention Among Sexual Minority Adults.
Journal of the American Heart Association. 9(24) [DOI] 10.1161/JAHA.120.018233. [PMID] 33317368.
2020
Risk and Blood Pressure Control Rates Across the Spectrum of Coronary Artery Disease in Hypertensive Women: An Analysis from The INternational VErapamil SR-Trandolapril STudy (INVEST).
Journal of women's health (2002). 29(2):158-166 [DOI] 10.1089/jwh.2018.7235. [PMID] 31403360.
2020
Resting coronary velocity and myocardial performance in women with impaired coronary flow reserve: Results from the Women’s Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction (WISE-CVD) study.
International journal of cardiology. 309:19-22 [DOI] 10.1016/j.ijcard.2020.01.053. [PMID] 32037132.
2020
Redefining Resistant Hypertension: A Comparison of Cardiovascular Risk Associated With the 2018 Versus 2008 American Heart Association Definitions for Resistant Hypertension.
Circulation. Cardiovascular quality and outcomes. 13(2) [DOI] 10.1161/CIRCOUTCOMES.119.005979. [PMID] 32008359.
2020
Psychological stress, cardiac symptoms, and cardiovascular risk in women with suspected ischaemia but no obstructive coronary disease.
Stress and health : journal of the International Society for the Investigation of Stress. 36(3):264-273 [DOI] 10.1002/smi.2928. [PMID] 31957961.
2020
Predicted Versus Observed Major Adverse Cardiac Event Risk in Women With Evidence of Ischemia and No Obstructive Coronary Artery Disease: A Report From WISE (Women’s Ischemia Syndrome Evaluation).
Journal of the American Heart Association. 9(7) [DOI] 10.1161/JAHA.119.013234. [PMID] 32268814.
2020
Optimizing Precision of Hypertension Care to Maximize Blood Pressure Control: A Pilot Study Utilizing a Smartphone App to Incorporate Plasma Renin Activity Testing.
Clinical and translational science. [DOI] 10.1111/cts.12922. [PMID] 33142006.
2020
Adverse Pregnancy Outcomes Are Associated with Reduced Coronary Flow Reserve in Women With Signs and Symptoms of Ischemia Without Obstructive Coronary Artery Disease: A Report from the Women’s Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction Study.
Journal of women's health (2002). 29(4):487-492 [DOI] 10.1089/jwh.2019.7925. [PMID] 31859580.
2020
N-Terminal pro-B-type natriuretic peptide and coronary microvascular dysfunction in women with preserved ejection fraction: A report from the Women’s Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction (WISE-CVD) study.
PloS one. 15(12) [DOI] 10.1371/journal.pone.0243213. [PMID] 33270715.
2020
Left ventricular mass and myocardial scarring in women with hypertensive disorders of pregnancy.
Open heart. 7(2) [DOI] 10.1136/openhrt-2020-001273. [PMID] 32763966.
2020
Even “WISE-R?”-an Update on the NHLBI-Sponsored Women’s Ischemia Syndrome Evaluation.
Current atherosclerosis reports. 22(8) [DOI] 10.1007/s11883-020-00852-w. [PMID] 32556630.
2020
Design, methodology and baseline characteristics of the Women’s Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction (WISE-CVD).
American heart journal. 220:224-236 [DOI] 10.1016/j.ahj.2019.11.017. [PMID] 31884245.
2020
Coronary Vascular Function and Cardiomyocyte Injury: A Report From the WISE-CVD.
Arteriosclerosis, thrombosis, and vascular biology. 40(12):3015-3021 [DOI] 10.1161/ATVBAHA.120.314260. [PMID] 33028098.
2020
Attended vs unattended systolic blood pressure measurement: A randomized comparison in patients with cardiovascular disease.
Journal of clinical hypertension (Greenwich, Conn.). 22(11):1987-1992 [DOI] 10.1111/jch.14037. [PMID] 32951360.
2020
Angina Hospitalization Rates in Women With Signs and Symptoms of Ischemia But no Obstructive Coronary Artery Disease: A Report from the WISE (Women’s Ischemia Syndrome Evaluation) Study.
Journal of the American Heart Association. 9(4) [DOI] 10.1161/JAHA.119.013168. [PMID] 32063125.
2020
Not typical angina and mortality in women with obstructive coronary artery disease: Results from the Women’s Ischemic Syndrome Evaluation study (WISE).
International journal of cardiology. Heart & vasculature. 27 [DOI] 10.1016/j.ijcha.2020.100502. [PMID] 32226820.
2019
Prevalence of Coronary Endothelial and Microvascular Dysfunction in Women with Symptoms of Ischemia and No Obstructive Coronary Artery Disease Is Confirmed by a New Cohort: The NHLBI-Sponsored Women’s Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction (WISE-CVD).
Journal of interventional cardiology. 2019 [DOI] 10.1155/2019/7169275. [PMID] 31772544.
2019
Multimodal Intervention to Improve Functional Status in Hypertensive Older Adults: A Pilot Randomized Controlled Trial.
Journal of clinical medicine. 8(2) [DOI] 10.3390/jcm8020196. [PMID] 30736317.
2019
Left ventricular concentric remodelling and functional impairment in women with ischaemia with no obstructive coronary artery disease and intermediate coronary flow reserve: a report from the WISE-CVD study.
European heart journal cardiovascular Imaging. 20(8):875-882 [DOI] 10.1093/ehjci/jez044. [PMID] 30904924.
2019
Increasing and Evolving Role of Smart Devices in Modern Medicine.
European cardiology. 14(3):181-186 [DOI] 10.15420/ecr.2019.02. [PMID] 31933689.
2019
Effect of all-extremity high-intensity interval training vs. moderate-intensity continuous training on aerobic fitness in middle-aged and older adults with type 2 diabetes: A randomized controlled trial.
Experimental gerontology. 116:46-53 [DOI] 10.1016/j.exger.2018.12.013. [PMID] 30576716.
2019
Late sodium channel blockade improves angina and myocardial perfusion in patients with severe coronary microvascular dysfunction: Women’s Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction ancillary study.
International journal of cardiology. 276:8-13 [DOI] 10.1016/j.ijcard.2018.09.081. [PMID] 30293664.
2018
Imbalance of gut microbiome and intestinal epithelial barrier dysfunction in patients with high blood pressure.
Clinical science (London, England : 1979). 132(6):701-718 [DOI] 10.1042/CS20180087. [PMID] 29507058.
2018
Intensive blood pressure lowering reduces adverse cardiovascular outcomes among patients with high-normal glucose: An analysis from the Systolic Blood Pressure Intervention Trial database.
Journal of clinical hypertension (Greenwich, Conn.). 20(4):620-624 [DOI] 10.1111/jch.13247. [PMID] 29532983.
2018
Ischemia and No Obstructive Coronary Artery Disease ( INOCA ): What Is the Risk?
Journal of the American Heart Association. 7(17) [DOI] 10.1161/JAHA.118.008868. [PMID] 30371178.
2018
It Takes a Team to Deliver Optimal Cardiovascular Care.
Journal of the American College of Cardiology. 72(8):948-951 [DOI] 10.1016/j.jacc.2018.07.017. [PMID] 30115233.
2018
Long-term mortality and estimated functional capacity among women with symptoms of ischemic heart disease: From the NHLBI-sponsored Women’s Ischemia Syndrome Evaluation.
American heart journal. 206:123-126 [DOI] 10.1016/j.ahj.2018.08.010. [PMID] 30237012.
2018
Maladaptive left ventricular remodeling in women: An analysis from the Women’s Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction study.
International journal of cardiology. 268:230-235 [DOI] 10.1016/j.ijcard.2018.03.139. [PMID] 30041793.
2018
Mortality implications of lower DBP with lower achieved systolic pressures in coronary artery disease: long-term mortality results from the INternational VErapamil-trandolapril STudy US cohort.
Journal of hypertension. 36(2):419-427 [DOI] 10.1097/HJH.0000000000001559. [PMID] 28938338.
2018
Myocardial Scar Is Prevalent and Associated With Subclinical Myocardial Dysfunction in Women With Suspected Ischemia But No Obstructive Coronary Artery Disease: From the Women’s Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction Study.
Circulation. 137(8):874-876 [DOI] 10.1161/CIRCULATIONAHA.117.031999. [PMID] 29459474.
2018
Weight cycling and cardiovascular outcome in women with suspected ischemia: A report from the NHLBI-sponsored WISE Study.
PloS one. 13(12) [DOI] 10.1371/journal.pone.0207223. [PMID] 30507935.
2018
Gut microbiota and serum metabolite differences in African Americans and White Americans with high blood pressure.
International journal of cardiology. 271:336-339 [DOI] 10.1016/j.ijcard.2018.04.074. [PMID] 30049487.
2017
Myocardial tissue deformation is reduced in subjects with coronary microvascular dysfunction but not rescued by treatment with ranolazine.
Clinical cardiology. 40(5):300-306 [DOI] 10.1002/clc.22660. [PMID] 28004395.
2017
Typical angina is associated with greater coronary endothelial dysfunction but not abnormal vasodilatory reserve.
Clinical cardiology. 40(10):886-891 [DOI] 10.1002/clc.22740. [PMID] 28605043.
2017
Ten-Year Mortality in the WISE Study (Women’s Ischemia Syndrome Evaluation).
Circulation. Cardiovascular quality and outcomes. 10(12) [DOI] 10.1161/CIRCOUTCOMES.116.003863. [PMID] 29217675.
2017
Sex impacts the flow-mediated dilation response to acute aerobic exercise in older adults.
Experimental gerontology. 91:57-63 [DOI] 10.1016/j.exger.2017.02.069. [PMID] 28216412.
2017
Metabolic costs of daily activity in older adults (Chores XL) study: design and methods.
Contemporary clinical trials communications. 6:1-8 [DOI] 10.1016/j.conctc.2017.02.003. [PMID] 28649668.
2017
Effect of Low-Furanocoumarin Hybrid Grapefruit Juice Consumption on Midazolam Pharmacokinetics.
Journal of clinical pharmacology. 57(3):305-311 [DOI] 10.1002/jcph.807. [PMID] 27503364.
2017
Acetylcholine versus cold pressor testing for evaluation of coronary endothelial function.
PloS one. 12(2) [DOI] 10.1371/journal.pone.0172538. [PMID] 28207868.
2017
All-Extremity Exercise Training Improves Arterial Stiffness in Older Adults.
Medicine and science in sports and exercise. 49(7):1404-1411 [DOI] 10.1249/MSS.0000000000001229. [PMID] 28166118.
2017
Evaluation of Cell Therapy on Exercise Performance and Limb Perfusion in Peripheral Artery Disease: The CCTRN PACE Trial (Patients With Intermittent Claudication Injected With ALDH Bright Cells).
Circulation. 135(15):1417-1428 [DOI] 10.1161/CIRCULATIONAHA.116.025707. [PMID] 28209728.
2017
Daily Activity Measured With Wearable Technology as a Novel Measurement of Treatment Effect in Patients With Coronary Microvascular Dysfunction: Substudy of a Randomized Controlled Crossover Trial.
JMIR research protocols. 6(12) [DOI] 10.2196/resprot.8057. [PMID] 29263019.
2016
A randomized, placebo-controlled trial of late Na current inhibition (ranolazine) in coronary microvascular dysfunction (CMD): impact on angina and myocardial perfusion reserve.
European heart journal. 37(19):1504-13 [DOI] 10.1093/eurheartj/ehv647. [PMID] 26614823.
2016
An injectable capillary-like microstructured alginate hydrogel improves left ventricular function after myocardial infarction in rats.
International journal of cardiology. 220:149-54 [DOI] 10.1016/j.ijcard.2016.06.158. [PMID] 27379917.
2016
Association between High Endocardial Unipolar Voltage and Improved Left Ventricular Function in Patients with Ischemic Cardiomyopathy.
Texas Heart Institute journal. 43(4):291-6 [DOI] 10.14503/THIJ-15-5341. [PMID] 27547135.
2016
Circulating progenitor cells and coronary microvascular dysfunction: Results from the NHLBI-sponsored Women’s Ischemia Syndrome Evaluation – Coronary Vascular Dysfunction Study (WISE-CVD).
Atherosclerosis. 253:111-117 [DOI] 10.1016/j.atherosclerosis.2016.08.026. [PMID] 27596135.
2016
Correction: Effects of Verapamil SR and Atenolol on 24-Hour Blood Pressure and Heart Rate in Hypertension Patients with Coronary Artery Disease: An International Verapamil SR-Trandolapril Ambulatory Monitoring Substudy.
PloS one. 11(6) [DOI] 10.1371/journal.pone.0157212. [PMID] 27258057.
2016
Long-Term Mortality in Hypertensive Patients With Coronary Artery Disease: Results From the US Cohort of the International Verapamil (SR)/Trandolapril Study.
Hypertension (Dallas, Tex. : 1979). 68(5):1110-1114 [PMID] 27620390.
View on: PubMed
2016
Mortality Risk Associated With Resistant Hypertension Among Women: Analysis from Three Prospective Cohorts Encompassing the Spectrum of Women’s Heart Disease.
Journal of women's health (2002). 25(10):996-1003 [PMID] 27224417.
View on: PubMed
2016
Novel all-extremity high-intensity interval training improves aerobic fitness, cardiac function and insulin resistance in healthy older adults.
Experimental gerontology. 82:112-9 [DOI] 10.1016/j.exger.2016.06.009. [PMID] 27346646.
2016
Psychosocial predictors of long-term mortality among women with suspected myocardial ischemia: the NHLBI-sponsored Women’s Ischemia Syndrome Evaluation.
Journal of behavioral medicine. 39(4):687-93 [DOI] 10.1007/s10865-016-9737-7. [PMID] 27017335.
2015
Renal function and coronary microvascular dysfunction in women with symptoms/signs of ischemia.
PloS one. 10(5) [DOI] 10.1371/journal.pone.0125374. [PMID] 25951606.
2015
Mild renal dysfunction and long-term adverse outcomes in women with chest pain: results from the National Heart, Lung, and Blood Institute-sponsored Women’s Ischemia Syndrome Evaluation (WISE).
American heart journal. 169(3):412-8 [DOI] 10.1016/j.ahj.2014.12.010. [PMID] 25728732.
2015
Impact of aspirin according to type of stable coronary artery disease: insights from a large international cohort.
The American journal of medicine. 128(2):137-43 [DOI] 10.1016/j.amjmed.2014.09.028. [PMID] 25447610.
2015
Relationships between components of metabolic syndrome and coronary intravascular ultrasound atherosclerosis measures in women without obstructive coronary artery disease: the NHLBI-Sponsored Women’s Ischemia Syndrome Evaluation Study.
Cardiovascular endocrinology. 4(2):45-52 [PMID] 26665010.
View on: PubMed
2015
Effects of verapamil SR and atenolol on 24-hour blood pressure and heart rate in hypertension patients with coronary artery disease: an international verapamil SR-trandolapril ambulatory monitoring substudy.
PloS one. 10(4) [DOI] 10.1371/journal.pone.0122726. [PMID] 25835002.
2015
Five-year stroke rate in women with signs and symptoms of ischemia undergoing coronary angiography: a retrospective study from the NHLBI-sponsored Women’s Ischemia Syndrome Evaluation (WISE).
JRSM open. 6(3) [DOI] 10.1177/2054270415577761. [PMID] 25893110.
2015
Cardiac magnetic resonance myocardial perfusion reserve index is reduced in women with coronary microvascular dysfunction. A National Heart, Lung, and Blood Institute-sponsored study from the Women’s Ischemia Syndrome Evaluation.
Circulation. Cardiovascular imaging. 8(4) [DOI] 10.1161/CIRCIMAGING.114.002481. [PMID] 25801710.
2015
2015 ACC Health Policy Statement on Cardiovascular Team-Based Care and the Role of Advanced Practice Providers.
Journal of the American College of Cardiology. 65(19):2118-36 [DOI] 10.1016/j.jacc.2015.03.550. [PMID] 25975476.
2014
TIMI frame count and adverse events in women with no obstructive coronary disease: a pilot study from the NHLBI-sponsored Women’s Ischemia Syndrome Evaluation (WISE).
PloS one. 9(5) [DOI] 10.1371/journal.pone.0096630. [PMID] 24800739.
2014
Relationships Between Depression, Dietary Habits, and Cardiovascular Mortality and Events Among Women With Suspected Myocardial Ischemia
Psychosomatic Medicine. 76(3)
2014
Recruiting for Acute Myocardial Infarction Cell Therapy Trials: Challenges and Best Practices for the CCTRN.
Clinical researcher (Alexandria, Va.). 28(4):71-77 [PMID] 25848636.
View on: PubMed
2014
Aldosterone inhibition and coronary endothelial function in women without obstructive coronary artery disease: an ancillary study of the national heart, lung, and blood institute-sponsored women’s ischemia syndrome evaluation.
American heart journal. 167(6):826-32 [DOI] 10.1016/j.ahj.2014.01.017. [PMID] 24890531.
2014
Depression, dietary habits, and cardiovascular events among women with suspected myocardial ischemia.
The American journal of medicine. 127(9):840-7 [DOI] 10.1016/j.amjmed.2014.04.011. [PMID] 24769297.
2014
Comparison of low and high dose intracoronary adenosine and acetylcholine in women undergoing coronary reactivity testing: results from the NHLBI-sponsored Women’s Ischemia Syndrome Evaluation (WISE).
International journal of cardiology. 172(1):e114-5 [DOI] 10.1016/j.ijcard.2013.12.120. [PMID] 24461979.
2014
Predictors and outcomes of resistant hypertension among patients with coronary artery disease and hypertension.
Journal of hypertension. 32(3):635-43 [DOI] 10.1097/HJH.0000000000000051. [PMID] 24299915.
2013
Number and function of bone-marrow derived angiogenic cells and coronary flow reserve in women without obstructive coronary artery disease: a substudy of the NHLBI-sponsored Women’s Ischemia Syndrome Evaluation (WISE).
PloS one. 8(12) [DOI] 10.1371/journal.pone.0081595. [PMID] 24312563.
2013
Clinical implications of the Women’s Ischemia Syndrome Evaluation: inter-relationships between symptoms, psychosocial factors and cardiovascular outcomes
Womens Health. 479-90 [DOI] 10.2217/whe.13.50. [PMID] 24007253.
2013
Clinical implications of the Women’s Ischemia Syndrome Evaluation: inter-relationships between symptoms, psychosocial factors and cardiovascular outcomes.
Women's health (London, England). 9(5):479-90 [DOI] 10.2217/whe.13.50. [PMID] 24007253.
2013
Electromechanical Assessment of Myocardial Function (Noga) Is Associated With Exercise Improvement in Patients Treated With Autologous Stem Cell Therapy for Refractory Angina
Journal of the American College of Cardiology. 61
2013
Electromechanical Assessment of Myocardial Function Is Associated With Improvement in Ejection Fraction in Patients Treated With Autologous Stem Cell Therapy for Ischemic Cardiomyopathy
Circulation. 128(22, S)
2013
Increased Circulating Progenitor Cells in Women With Microvascular Coronary Dysfunction: Results From the Nhlbi-Sponsored Women’s Ischemia Syndrome Evaluation – Coronary Vascular Dysfunction Study (Wise-Cvd)
Circulation. 128(22, S)
2013
Mild Renal Insufficiency Is An Independent Predictor of Coronary Microvascular Dysfunction Among Women With Symptoms/Signs of Ischemia: a Report From the Women’s Ischemia Syndrome Evaluation (Wise)
Circulation. 128(22, S)
2013
Mild Renal Insufficiency Predicts Mortality and Adverse Events in Women With Cardiac Ischemia, Independent of the Underlying Obstructive Coronary Artery Disease
Circulation. 128(22, S)
2013
Mortality implications of angina and blood pressure in hypertensive patients with coronary artery disease: New data from extended follow-up of the International Verapamil/Trandolapril Study (INVEST).
Clinical cardiology. 36(8):442-7 [DOI] 10.1002/clc.22145. [PMID] 23720247.
2013
Anginal symptoms, coronary artery disease, and adverse outcomes in Black and White women: the NHLBI-sponsored Women’s Ischemia Syndrome Evaluation (WISE) study.
Journal of women's health (2002). 22(9):724-32 [DOI] 10.1089/jwh.2012.4031. [PMID] 23992103.
2013
Simple integer risk score to determine prognosis of patients with hypertension and chronic stable coronary artery disease.
Journal of the American Heart Association. 2(4) [DOI] 10.1161/JAHA.113.000205. [PMID] 23948642.
2012
An Injectable Acellular Capillary Hydrogel Improves Left Ventricular Function After Myocardial Infarction
Journal of the American College of Cardiology. 59
2012
Treatment-Resistant Blood Pressure Among Patients With Coronary Artery Disease – Cause for Concern: New Data From the Extended Follow-Up of the International Verapamail Sr-Trandolapril Study (Invest)
Journal of the American College of Cardiology. 59
2012
Safety of coronary reactivity testing in women with no obstructive coronary artery disease: results from the NHLBI-sponsored WISE (Women’s Ischemia Syndrome Evaluation) study.
JACC. Cardiovascular interventions. 5(6):646-53 [DOI] 10.1016/j.jcin.2012.01.023. [PMID] 22721660.
2012
Relationships Between Components of Metabolic Syndrome and Coronary Intravascular Ultrasound (Ivus) Atherosclerosis Measures in Women Without Obstructive Coronary Artery Disease: the Nhlbi-Sponsored Women’S Ischemia Syndrome Evaluation (Wise) Study
Journal of the American College of Cardiology. 59(13, S)
2012
Relationships between cardiovascular disease risk factors and depressive symptoms as predictors of cardiovascular disease events in women.
Journal of women's health (2002). 21(2):133-9 [DOI] 10.1089/jwh.2011.2787. [PMID] 21988550.
2012
Mortality Associated With Angina and Blood Pressure Control Among Hypertensive Patients With Coronary Artery Disease: New Data From Extended Follow-Up of the International Verapamil/Trandolapril Study
Journal of the American College of Cardiology. 59
2012
Mortality Associated With Angina and Blood Pressure Control Among Hypertensive Patients With Coronary Artery Disease: New Data From Extended Follow-Up of the International Verapamil/Trandolapril Study
Journal of the American College of Cardiology. 59
2012
A degradable, bioactive, gelatinized alginate hydrogel to improve stem cell/growth factor delivery and facilitate healing after myocardial infarction.
Medical hypotheses. 79(5):673-7 [DOI] 10.1016/j.mehy.2012.08.006. [PMID] 22939314.
2012
How do guidelines impact measures of performance? Can they keep up?
Archives of internal medicine. 172(12):945-6 [DOI] 10.1001/archinternmed.2012.2261. [PMID] 22641271.
2012
Effect of transendocardial delivery of autologous bone marrow mononuclear cells on functional capacity, left ventricular function, and perfusion in chronic heart failure: the FOCUS-CCTRN trial.
JAMA. 307(16):1717-26 [DOI] 10.1001/jama.2012.418. [PMID] 22447880.
2012
Effect of the use and timing of bone marrow mononuclear cell delivery on left ventricular function after acute myocardial infarction: the TIME randomized trial.
JAMA. 308(22):2380-9 [PMID] 23129008.
View on: PubMed
2012
Differential Effects of Cold Pressor and Acetylcholine During Endothelial Function Assessment in Women With No Obstructive Coronary Artery Disease: the Nhlbi-Sponsored Women’S Ischemia Syndrome Evaluation (Wise) Study
Journal of the American College of Cardiology. 59
2012
Combining psychosocial data to improve prediction of cardiovascular disease risk factors and events: The National Heart, Lung, and Blood Institute–sponsored Women’s Ischemia Syndrome Evaluation study.
Psychosomatic medicine. 74(3):263-70 [DOI] 10.1097/PSY.0b013e31824a58ff. [PMID] 22434916.
2012
Modest increase in peak VO2 is related to better clinical outcomes in chronic heart failure patients: results from heart failure and a controlled trial to investigate outcomes of exercise training.
Circulation. Heart failure. 5(5):579-85 [PMID] 22773109.
View on: PubMed
2011
Relationship Between Coronary Micro- and Macrovascular Measures in Women With Chest Pain Without Significant Coronary Artery Disease: An Ancillary Substudy From the Nhbli-Sponsored Women’s Ischemia Syndrome Evaluation (Wise)
Journal of the American College of Cardiology. 57
2011
President’s page: team-based care: a solution for our health care delivery challenges.
Journal of the American College of Cardiology. 57(9):1123-5 [DOI] 10.1016/j.jacc.2011.02.003. [PMID] 21349405.
2011
Oversight and management of a cell therapy clinical trial network: experience and lessons learned.
Contemporary clinical trials. 32(5):614-9 [DOI] 10.1016/j.cct.2011.05.003. [PMID] 21616173.
2011
Harmful effects of NSAIDs among patients with hypertension and coronary artery disease.
The American journal of medicine. 124(7):614-20 [DOI] 10.1016/j.amjmed.2011.02.025. [PMID] 21596367.
2011
In women with symptoms of cardiac ischemia, nonobstructive coronary arteries, and microvascular dysfunction, angiotensin-converting enzyme inhibition is associated with improved microvascular function: A double-blind randomized study from the National Heart, Lung and Blood Institute Women’s Ischemia Syndrome Evaluation (WISE).
American heart journal. 162(4):678-84 [DOI] 10.1016/j.ahj.2011.07.011. [PMID] 21982660.
2011
Effect of intracoronary delivery of autologous bone marrow mononuclear cells 2 to 3 weeks following acute myocardial infarction on left ventricular function: the LateTIME randomized trial.
JAMA. 306(19):2110-9 [DOI] 10.1001/jama.2011.1670. [PMID] 22084195.
2011
Does Angiotensin Plus Aldosterone Inhibition Improve Coronary Endothelial Function? An Ancillary Study From the Nhlbi-Sponsored Women’s Ischemia Syndrome Evaluation (Wise)
Journal of the American College of Cardiology. 57
2011
Could Retinal Imaging Provide a Simple, Inexpensive, Noninvasive Index for Coronary Microvascular Function in Women With Chest Pain and Nonobstructive Coronary Artery Disease? An Ancillary Pilot Study From the Nhlbi-Sponsored Women’s Ischemia Syndrome Evaluation (Wise-Aric)
Journal of the American College of Cardiology. 57
2011
Antiplatelet therapy in acute coronary syndromes: implications for nursing practice.
The Journal of cardiovascular nursing. 26(3):239-49 [DOI] 10.1097/JCN.0b013e3181f1e3bd. [PMID] 21483251.
2011
Effect of phosphodiesterase type 5 inhibition on microvascular coronary dysfunction in women: a Women’s Ischemia Syndrome Evaluation (WISE) ancillary study.
Clinical cardiology. 34(8):483-7 [DOI] 10.1002/clc.20935. [PMID] 21780138.
2010
Tight blood pressure control and cardiovascular outcomes among hypertensive patients with diabetes and coronary artery disease.
JAMA. 304(1):61-8 [DOI] 10.1001/jama.2010.884. [PMID] 20606150.
2010
Outcomes Among hypertensive patients with concomitant peripheral and coronary artery disease: findings from the INternational VErapamil-SR/Trandolapril STudy.
Hypertension (Dallas, Tex. : 1979). 55(1):48-53 [DOI] 10.1161/HYPERTENSIONAHA.109.142240. [PMID] 19996066.
2010
Coronary revascularization strategy and outcomes according to blood pressure (from the International Verapamil SR-Trandolapril Study [INVEST]).
The American journal of cardiology. 106(4):498-503 [DOI] 10.1016/j.amjcard.2010.03.056. [PMID] 20691307.
2010
A randomized controlled trial of low-dose hormone therapy on myocardial ischemia in postmenopausal women with no obstructive coronary artery disease: results from the National Institutes of Health/National Heart, Lung, and Blood Institute-sponsored Women’s Ischemia Syndrome Evaluation (WISE).
American heart journal. 159(6):987.e1-7 [DOI] 10.1016/j.ahj.2010.03.024. [PMID] 20569710.
2010
Blood pressure and outcomes in very old hypertensive coronary artery disease patients: an INVEST substudy.
The American journal of medicine. 123(8):719-26 [DOI] 10.1016/j.amjmed.2010.02.014. [PMID] 20670726.
2010
An intravascular ultrasound analysis in women experiencing chest pain in the absence of obstructive coronary artery disease: a substudy from the National Heart, Lung and Blood Institute-Sponsored Women’s Ischemia Syndrome Evaluation (WISE).
Journal of interventional cardiology. 23(6):511-9 [DOI] 10.1111/j.1540-8183.2010.00598.x. [PMID] 21029178.
2010
Coronary microvascular reactivity to adenosine predicts adverse outcome in women evaluated for suspected ischemia results from the National Heart, Lung and Blood Institute WISE (Women’s Ischemia Syndrome Evaluation) study.
Journal of the American College of Cardiology. 55(25):2825-32 [DOI] 10.1016/j.jacc.2010.01.054. [PMID] 20579539.
2009
Adverse cardiovascular outcomes in women with nonobstructive coronary artery disease: a report from the Women’s Ischemia Syndrome Evaluation Study and the St James Women Take Heart Project.
Archives of internal medicine. 169(9):843-50 [DOI] 10.1001/archinternmed.2009.50. [PMID] 19433695.
2009
Characteristics and outcomes of revascularized patients with hypertension: an international verapamil SR-trandolapril substudy.
Hypertension (Dallas, Tex. : 1979). 53(4):624-30 [DOI] 10.1161/HYPERTENSIONAHA.108.111542. [PMID] 19237684.
2009
Depression and cardiovascular health care costs among women with suspected myocardial ischemia: prospective results from the WISE (Women’s Ischemia Syndrome Evaluation) Study.
Journal of the American College of Cardiology. 53(2):176-83 [DOI] 10.1016/j.jacc.2008.09.032. [PMID] 19130986.
2009
Incident Or Continued Angina During Hypertension Treatment Is Associated With Increased Risk of Death, Mi, Or Stroke Among Patients With Known Cad: a Substudy of the International Verapamil/Trandolapril Study (Invest)
Circulation. 120:S440-S441
2009
INVEST revisited: review of findings from the International Verapamil SR-Trandolapril Study.
Expert review of cardiovascular therapy. 7(11):1329-40 [DOI] 10.1586/erc.09.102. [PMID] 19900016.
2009
Long-Term Mortality Associated With New Onset Diabetes in Hypertensive Cad Patients Following Exposure To Antihypertensive Medications: Findings From the International Verapamail Sr-Trandolapril Study (Invest)
Journal of the American College of Cardiology. 53
2009
Multimarker approach predicts adverse cardiovascular events in women evaluated for suspected ischemia: results from the National Heart, Lung, and Blood Institute-sponsored Women’s Ischemia Syndrome Evaluation.
Clinical cardiology. 32(5):244-50 [DOI] 10.1002/clc.20454. [PMID] 19452486.
2009
New York Heart Association functional class predicts exercise parameters in the current era.
American heart journal. 158(4 Suppl):S24-30 [DOI] 10.1016/j.ahj.2009.07.017. [PMID] 19782785.
2009
Systolic blood pressure and subjective well-being in patients with coronary artery disease.
Clinical cardiology. 32(11):627-32 [DOI] 10.1002/clc.20501. [PMID] 19711440.
2008
Pulse pressure and adverse outcomes in women: a report from the Women’s Ischemia Syndrome Evaluation (WISE).
American journal of hypertension. 21(11):1224-30 [DOI] 10.1038/ajh.2008.268. [PMID] 18802432.
2008
Impact of resting heart rate on outcomes in hypertensive patients with coronary artery disease: findings from the INternational VErapamil-SR/trandolapril STudy (INVEST).
European heart journal. 29(10):1327-34 [DOI] 10.1093/eurheartj/ehn123. [PMID] 18375982.
2007
Coronary microvascular reactivity is only partially predicted by atherosclerosis risk factors or coronary artery disease in women evaluated for suspected ischemia: results from the NHLBI Women’s Ischemia Syndrome Evaluation (WISE).
Clinical cardiology. 30(2):69-74 [PMID] 17326061.
View on: PubMed
2007
Influence of Hispanic ethnicity on blood pressure control and cardiovascular outcomes in women with CAD and hypertension: findings from INVEST.
Journal of women's health (2002). 16(5):632-40 [PMID] 17627399.
View on: PubMed
2007
The ICD shock and stress management program: a randomized trial of psychosocial treatment to optimize quality of life in ICD patients.
Pacing and clinical electrophysiology : PACE. 30(7):858-64 [PMID] 17584267.
View on: PubMed
2006
Validating a self-report measure of global subjective well-being to predict adverse clinical outcomes.
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation. 15(4):675-86 [PMID] 16688500.
View on: PubMed
2006
Quality of death: implantable cardioverter defibrillators and proactive care.
Pacing and clinical electrophysiology : PACE. 29(6):637-42 [PMID] 16784431.
View on: PubMed
2006
Predictors of adverse outcome among patients with hypertension and coronary artery disease.
Journal of the American College of Cardiology. 47(3):547-51 [PMID] 16458134.
View on: PubMed
2006
The value of estimated functional capacity in estimating outcome: results from the NHBLI-Sponsored Women’s Ischemia Syndrome Evaluation (WISE) Study.
Journal of the American College of Cardiology. 47(3 Suppl):S36-43 [PMID] 16458169.
View on: PubMed
2006
Impaired coronary vascular reactivity and functional capacity in women: results from the NHLBI Women’s Ischemia Syndrome Evaluation (WISE) Study.
Journal of the American College of Cardiology. 47(3 Suppl):S44-9 [PMID] 16458171.
View on: PubMed
2006
End-of-life issues in elderly patients with acute coronary syndrome: the role of the cardiovascular nurse.
Progress in cardiovascular nursing. 21(3):151-5 [PMID] 16957462.
View on: PubMed
2006
Managing congestive heart failure patient factors in the device era.
Congestive heart failure (Greenwich, Conn.). 12(6):335-40 [PMID] 17170588.
View on: PubMed
2005
A Study of Antihypertensive Drugs and Depressive Symptoms (SADD-Sx) in patients treated with a calcium antagonist versus an atenolol hypertension Treatment Strategy in the International Verapamil SR-Trandolapril Study (INVEST).
Psychosomatic medicine. 67(3):398-406 [PMID] 15911902.
View on: PubMed
2005
Hostility scores are associated with increased risk of cardiovascular events in women undergoing coronary angiography: a report from the NHLBI-Sponsored WISE Study.
Psychosomatic medicine. 67(4):546-52 [PMID] 16046366.
View on: PubMed
2005
Improving perinatal and neonatal patient safety: The AHRQ patient safety indicators.
The Journal of perinatal & neonatal nursing. 19(1):15-23 [PMID] 15796421.
View on: PubMed
2005
Management of heart failure after cardiac resynchronization therapy: integrating advanced heart failure treatment with optimal device function.
Journal of the American College of Cardiology. 46(12):2193-8 [PMID] 16360045.
View on: PubMed
2004
Relationship of physical fitness vs body mass index with coronary artery disease and cardiovascular events in women.
JAMA. 292(10):1179-87 [PMID] 15353530.
View on: PubMed
2004
Psychosocial intervention for a geriatric patient to address fears related to implantable cardioverter defibrillator discharges.
Psychosomatics. 45(2):140-4 [PMID] 15016928.
View on: PubMed
2004
Expanding the scope of practice for cardiac rehabilitation: managing patients with implantable cardioverter defibrillators.
Journal of cardiopulmonary rehabilitation. 24(4):209-15 [PMID] 15286525.
View on: PubMed
2004
Hemoglobin level is an independent predictor for adverse cardiovascular outcomes in women undergoing evaluation for chest pain: results from the National Heart, Lung, and Blood Institute Women’s Ischemia Syndrome Evaluation Study.
Journal of the American College of Cardiology. 43(11):2009-14 [PMID] 15172405.
View on: PubMed
2004
Characteristics of contemporary patients with hypertension and coronary artery disease.
Clinical cardiology. 27(10):571-6 [PMID] 15553310.
View on: PubMed
2004
Acute and chronic psychological stress in coronary disease.
Current opinion in cardiology. 19(5):494-9 [PMID] 15316459.
View on: PubMed
2004
Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women’s Ischemia Syndrome Evaluation (WISE).
Circulation. 109(6):722-5 [PMID] 14970106.
View on: PubMed
2004
Emergency Treatment and Labor Act (EMTALA). Avoiding the pitfalls.
The Journal of perinatal & neonatal nursing. 18(2):103-14; quiz 115 [PMID] 15214249.
View on: PubMed
2003
A calcium antagonist vs a non-calcium antagonist hypertension treatment strategy for patients with coronary artery disease. The International Verapamil-Trandolapril Study (INVEST): a randomized controlled trial.
JAMA. 290(21):2805-16 [PMID] 14657064.
View on: PubMed
2002
Evaluating women with chest pain for the diagnosis of coronary artery disease.
Disease-a-month : DM. 48(10):647-58 [PMID] 12562052.
View on: PubMed
2001
Characteristics of patients with coronary artery disease and hypertension: a report from INVEST.
Clinical cardiology. 24(11 Suppl):V6-8 [PMID] 11712775.
View on: PubMed
2001
Electronic prescribing via the internet for a coronary artery disease and hypertension megatrial.
Clinical cardiology. 24(11 Suppl):V14-6 [PMID] 11712771.
View on: PubMed
2001
Fear of exertion following ICD storm: considering ICD shock and learning history.
Journal of cardiopulmonary rehabilitation. 21(1):47-9 [PMID] 11271657.
View on: PubMed
2001
The vascular biology of hypertension and atherosclerosis and intervention with calcium antagonists and angiotensin-converting enzyme inhibitors.
Clinical cardiology. 24(11 Suppl):V1-5 [PMID] 11712769.
View on: PubMed
2001
Young at heart: understanding the unique psychosocial adjustment of young implantable cardioverter defibrillator recipients.
Pacing and clinical electrophysiology : PACE. 24(7):1113-7 [PMID] 11475828.
View on: PubMed
2000
Weight cycling and high-density lipoprotein cholesterol in women: evidence of an adverse effect: a report from the NHLBI-sponsored WISE study. Women’s Ischemia Syndrome Evaluation Study Group.
Journal of the American College of Cardiology. 36(5):1565-71 [PMID] 11079659.
View on: PubMed
1998
Rationale and design of the International Verapamil SR/Trandolapril Study (INVEST): an Internet-based randomized trial in coronary artery disease patients with hypertension.
Journal of the American College of Cardiology. 32(32(5)):1228-1237 [DOI] 10.1016/S0735-1097(98)00423-9. [PMID] 9809930.
1998
Rationale and design of the International Verapamil SR/Trandolapril Study (INVEST): an Internet-based randomized trial in coronary artery disease patients with hypertension.
Journal of the American College of Cardiology. 32(5):1228-37 [PMID] 9809930.
View on: PubMed
1997
Effects of intermittent transdermal nitroglycerin on occurrence of ischemia after patch removal: results of the second transdermal intermittent dosing evaluation study (TIDES-II).
Journal of the American College of Cardiology. 30(4):955-61 [PMID] 9316524.
View on: PubMed
1996
Factors limiting the enrollment of women in a randomized coronary artery disease trial. The Asymptomatic Cardiac Ischemia Pilot Study (ACIP) Investigators.
Clinical cardiology. 19(8):614-8 [PMID] 8864334.
View on: PubMed
1994
Characteristics of a contemporary population with angina pectoris. TIDES Investigators.
The American journal of cardiology. 74(3):226-31 [PMID] 8037126.
View on: PubMed
1994
Effects of treatment on outcome in mildly symptomatic patients with ischemia during daily life. The Atenolol Silent Ischemia Study (ASIST)
Circulation. 90(2):762-8 [PMID] 8044945.
View on: PubMed
1992
Clot busters. The future of EMS thrombolytics.
JEMS : a journal of emergency medical services. 17(4):74-5, 77 [PMID] 10117529.
View on: PubMed
1991
Risk management in outpatient cardiac catheterization clinics.
Perspectives in healthcare risk management. 11(2):16-20 [PMID] 10109933.
View on: PubMed
1991
The prognostic and economic implications of a strategy to detect and treat asymptomatic ischemia: the Atenolol Silent Ischemia Trial (ASIST) protocol.
Clinical cardiology. 14(6):457-62 [PMID] 1810681.
View on: PubMed

Grants

Jul 2020 ACTIVE
The Microvascular Aging and Eicosanoids Womens Evaluation of Systemic aging Tenacity (MAE-WEST) Specialized Center of Research Excellence (SCORE) on Sex Differences
Role: Co-Investigator
Funding: CEDARS SINAI MEDICAL CTR via NATL INST OF HLTH NIA
Jul 2020 ACTIVE
ACTIV-4 Infected Outpatient Study
Role: Principal Investigator
Funding: UNIV OF PITTSBURGH via NATL INST OF HLTH NHLBI
Apr 2020 ACTIVE
PCORI_Transfer from PCRF OneFlorida Clinical Research Consortium
Role: Project Manager
Funding: PATIENT-CENTERED OUTCOMES RES INST
Sep 2019 ACTIVE
Sex Differences in Chronic and Acute Vascular Responses to Aerobic Exercise in Older Adults
Role: Co-Investigator
Funding: NATL INST OF HLTH NIA
May 2019 ACTIVE
Womens Ischemia Syndrome Evaluation (WISE) Mechanisms of Coronary Microvascular Dysfunction Leading to Pre-Heart Failure with Preserved Ejection Fraction (HFpEF)
Role: Co-Investigator
Funding: CEDARS SINAI MEDICAL CTR via NATL INST OF HLTH NHLBI
Jan 2019 – Sep 2020
PCRF: OneFlorida Clinical Research Consortium
Role: Other
Funding: PEOPLE CENTERED RES FOU via PATIENT-CENTERED OUTCOMES RES INST
Sep 2018 ACTIVE
An integrated human organ-on-chip ultrasensitive miRNA detection platform for novel biomarker discovery
Role: Principal Investigator
Funding: UNIV OF NOTRE DAME via NATL INST OF HLTH NHLBI
Jul 2018 ACTIVE
Southeast Enrollment Center (SEEC)
Role: Project Manager
Funding: UNIV OF MIAMI via NATL INST OF HLTH OD
Sep 2017 ACTIVE
Women's Ischemia Trial to Reduce Events in Non-Obstructive CAD (WARRIOR)
Role: Co-Investigator
Funding: US ARMY MED RES ACQUISITION
Sep 2016 ACTIVE
Aspirin Dosing: A Patient-Centric Trial Assessing Benefits and Long-term Effectiveness (ADAPTABLE)
Role: Co-Investigator
Funding: DUKE UNIV via PATIENT-CENTERED OUTCOMES RES INST
Feb 2016 – Sep 2019
INfluenza Vaccine to Effectively Stop Cardio Thoracic Events and Decompensated heart failure (INVESTED)
Role: Co-Investigator
Funding: BRIGHAM AND WOMENS HOSPITAL via NATL INST OF HLTH NHLBI
Oct 2015 – Mar 2019
OneFlorida Clinical Research Consortium Phase II
Role: Co-Investigator
Funding: PATIENT-CENTERED OUTCOMES RES INST
Sep 2015 – Dec 2018
Endothelial Dysfunction in Older Adults with Type 2 Diabetes: Effect of Exercise
Role: Project Manager
Funding: NATL INST OF HLTH NIA
Sep 2015 – Mar 2018
PEAKS: Validation of mobile technologies for clinical assessment, monitoring, and intervention
Role: Project Manager
Funding: EVERYFIT INC via NATL INST OF HLTH
May 2015 – Apr 2016
Optimizing Rural Health Clinic Infrastructure to Maximize BP Control (OPTI-BP)
Role: Project Manager
Funding: FL HLTH EQUITY RESEARCH INST
Jul 2013 – Mar 2019
Metabolic Costs of Daily Activities in Older Adults
Role: Project Manager
Funding: NATL INST OF HLTH NIA
Mar 2012 – Aug 2020
UFRCC for Cardiovascular Cell Therapy Research Network
Role: Co-Investigator
Funding: NATL INST OF HLTH NHLBI

Patents

Issued November 1999
Method & System For Interactive Prescription and Distribution of Perscriptions in Conducting Medical Studies (CON)
#5,991,731
Published April 2004
Combination Drug Therapy for Treating Hypertension
#US 2005-0032784 A1

Education

ARNP
1991 · University of Florida
Master's of Science – Nursing
1989 · University of Florida

Teaching Profile

Courses Taught
2015
GMS7093 Introduction to Clinical and Translational Research

Contact Details

Phones:
Business:
(352) 273-8944
Emails:
Administrative Spec I: