Keith March

Keith March,

VA Faculty

Department: MD-CARDIOLOGY
Business Phone: (352) 294-8620

About Keith March

My name is Keith L. March, MD, PhD, and I am a cardiologist, inventor, passionate pioneer in the field of regenerative medicine and the founding director of the University of Florida Center for Regenerative Medicine. My lifelong curiosity and dedication to medicine are rooted in my personal history, dating back to the age of 6 when my grandfather experienced a heart attack. This pivotal moment sparked a fascination with cardiology and a growing interest in biology and chemistry that shaped my career trajectory.

Aided by the guidance of exceptional mentors, I chose cardiology as my specialization, enticed by the profound potential of interventional devices, imaging, molecular biology and gene therapy. I was excited by the idea of delivering genes and cells by developing advanced delivery devices for use in catheterization laboratories. I saw a great opportunity in the field of cardiology to significantly contribute to the then-emerging understanding of vascular cell and molecular biology.

I bring a very personal perspective to my practice, which is underpinned by deep respect for my patients and gratitude for the opportunity to care for them, especially in the context of leading-edge trials addressing unmet medical needs. The empathetic connection I foster with my patients and their families is a cornerstone of my approach to medicine, as I work to integrate breakthrough cell therapy and regenerative medicine approaches into medical practice.

My research interests are centered around utilizing adult stem cells, or cell-based therapeutics, to repair the body and provide relief for patients grappling with a wide array of diseases. My ultimate goal is to introduce innovative new therapeutics to treat patients both locally and globally.

Over the years, I have been actively involved in several organizations. I am a past president of the International Federation for Adipose Therapeutics and Science, the leading organization advancing adipose (fat) cell-derived therapies, and have served as its board member for two decades. I have also had the privilege of chairing the National Institutes of Health Data and Safety Monitoring Board (DSMB) gene and cell therapy for several years, overseeing clinical trials in that arena.

Under my leadership, the UF Center for Regenerative Medicine is proceeding with clinical trials for patients battling diseases such as advanced heart failure, autoimmune diseases like dermatomyositis and polymyositis, inherited diseases including muscular dystrophy and degenerative diseases such as arthritis pain syndromes.

In my spare time, I am an avid outdoorsman, having spent the last two decades horse riding with my family. I particularly enjoy gaited horses, such as the Tennessee Walker, and my family has also trained Icelandic horses. On the other end of the transportation spectrum, I am also an instrument-rated pilot, a skill acquired during my medical training and residency. Although the demands of my profession have limited flying in recent years, I have greatly enjoyed piloting various aircraft, particularly high-wing retractable gear four-place aircraft, taking colleagues and friends on trips across the country for professional meetings and vacations.

I consider myself a medical professional who blends passion, dedication and empathy. My unwavering commitment to advancing medical research and providing patient-centered care continues to move the UF Center for Regenerative Medicine forward.

Teaching Profile

Courses Taught
2019-2024
IDH3931 Interdisciplinary Junior Honors
2018
MDT7090 Elective Topics
2022
GMS6335 Advanced Stem Cell Biology: Tissue Engineering
2023
GMS6331 Stem Cell Biology
2023
GMS6336 Advanced Stem Cell Biology: Regenerative Medicine

Publications

2024
Comparison of different porcine models simulating myocardial cold ischemia of pediatric donor hearts.
Perfusion. [DOI] 10.1177/02676591241226464. [PMID] 38391296.
2023
Diminished vasculogenesis under inflammatory conditions is mediated by Activin A.
Angiogenesis. 26(3):423-436 [DOI] 10.1007/s10456-023-09873-w. [PMID] 36977946.
2023
Extracellular vesicles as personalized medicine.
Molecular aspects of medicine. 91 [DOI] 10.1016/j.mam.2022.101155. [PMID] 36456416.
2023
Notch Pathways Regulate Expression of Angiostatic Factor Activin A in Endothelial-Pericyte-Like Mesenchymal Stromal Cell Interactions.
Stem cells and development. 32(11-12):301-313 [DOI] 10.1089/scd.2023.0003. [PMID] 36924295.
2022
Bone marrow- or adipose-mesenchymal stromal cell secretome preserves myocardial transcriptome profile and ameliorates cardiac damage following ex vivo cold storage.
Journal of molecular and cellular cardiology. 164:1-12 [DOI] 10.1016/j.yjmcc.2021.11.002. [PMID] 34774548.
2022
Development of a student-driven undergraduate program in regenerative medicine.
Regenerative medicine. 17(10):755-765 [DOI] 10.2217/rme-2022-0069. [PMID] 35924471.
2022
Efficacy and Safety of MSC Cell Therapies for Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis.
Stem cells translational medicine. 11(7):688-703 [DOI] 10.1093/stcltm/szac032. [PMID] 35640138.
2022
Human Heart Anoxia and Reperfusion Tissue (HEART) Model for the Rapid Study of Exosome Bound miRNA Expression As Biomarkers for Myocardial Infarction.
Small (Weinheim an der Bergstrasse, Germany). 18(28) [DOI] 10.1002/smll.202201330. [PMID] 35670145.
2022
Mesenchymal stem cell secretions improve donor heart function following ex vivo cold storage.
The Journal of thoracic and cardiovascular surgery. 163(4):e277-e292 [DOI] 10.1016/j.jtcvs.2020.08.095. [PMID] 32981709.
2022
Non-homologous use of adipose-derived cell and tissue therapies: Osteoarthritis as a case study.
Bone reports. 17 [DOI] 10.1016/j.bonr.2022.101601. [PMID] 35874168.
2022
Recommendations for nomenclature and definition of cell products intended for human cardiovascular use.
Cardiovascular research. 118(11):2428-2436 [DOI] 10.1093/cvr/cvab270. [PMID] 34387303.
2021
A multiplexed ion-exchange membrane-based miRNA (MIX·miR) detection platform for rapid diagnosis of myocardial infarction.
Lab on a chip. 21(20):3876-3887 [DOI] 10.1039/d1lc00685a. [PMID] 34546237.
2021
A Phase II study of autologous mesenchymal stromal cells and c-kit positive cardiac cells, alone or in combination, in patients with ischaemic heart failure: the CCTRN CONCERT-HF trial.
European journal of heart failure. 23(4):661-674 [DOI] 10.1002/ejhf.2178. [PMID] 33811444.
2021
Adipose stem cell secretome markedly improves rodent heart and human induced pluripotent stem cell-derived cardiomyocyte recovery from cardioplegic transport solution exposure.
Stem cells (Dayton, Ohio). 39(2):170-182 [DOI] 10.1002/stem.3296. [PMID] 33159685.
2021
Lactate Dehydrogenase B and Pyruvate Oxidation Pathway Associated With Carfilzomib-Related Cardiotoxicity in Multiple Myeloma Patients: Result of a Multi-Omics Integrative Analysis.
Frontiers in cardiovascular medicine. 8 [DOI] 10.3389/fcvm.2021.645122. [PMID] 33996940.
2021
Newly diagnosed cardiovascular disease in patients treated with immune checkpoint inhibitors: a retrospective analysis of patients at an academic tertiary care center.
Cardio-oncology (London, England). 7(1) [DOI] 10.1186/s40959-021-00097-9. [PMID] 33736707.
2020
Allogeneic Mesenchymal Cell Therapy in Anthracycline-Induced Cardiomyopathy Heart Failure Patients: The CCTRN SENECA Trial.
JACC. CardioOncology. 2(4):581-595 [DOI] 10.1016/j.jaccao.2020.09.001. [PMID] 33403362.
2020
Arguments for a Different Regulatory Categorization and Framework for Stromal Vascular Fraction.
Stem cells and development. 29(5):257-262 [DOI] 10.1089/scd.2019.0096. [PMID] 31797749.
2020
Cardiac stem cell therapy among Clinics of Uncertain Regulatory Status (COURS): under-regulated, under-observed, incompletely understood.
Journal of translational medicine. 18(1) [DOI] 10.1186/s12967-020-02425-6. [PMID] 32678051.
2020
Immune Dysregulation in HFpEF: A Target for Mesenchymal Stem/Stromal Cell Therapy.
Journal of clinical medicine. 9(1) [DOI] 10.3390/jcm9010241. [PMID] 31963368.
2020
Therapeutic Use of Adipose-Derived Stromal Cells in a Murine Model of Acute Pancreatitis.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. 24(1):67-75 [DOI] 10.1007/s11605-019-04411-w. [PMID] 31745900.
2020
Tissue Engineering Clinical Council Roundtable Discussion: Opportunities and Challenges in Clinical Translation.
Tissue engineering. Part A. 26(3-4):113-119 [DOI] 10.1089/ten.tea.2019.0037. [PMID] 31977299.
2020
Whole-Body Vibration Training Increases Stem/Progenitor Cell Circulation Levels and May Attenuate Inflammation.
Military medicine. 185(Suppl 1):404-412 [DOI] 10.1093/milmed/usz247. [PMID] 32074302.
2019
Identifying Cancer Patients at Risk for Heart Failure Using Machine Learning Methods.
AMIA … Annual Symposium proceedings. AMIA Symposium. 2019:933-941 [PMID] 32308890.
2018
Adipose-derived stem cell conditioned medium impacts asymptomatic peripheral neuromuscular denervation in the mutant superoxide dismutase (G93A) transgenic mouse model of amyotrophic lateral sclerosis.
Restorative neurology and neuroscience. 36(5):621-627 [DOI] 10.3233/RNN-180820. [PMID] 30010155.
2018
AMD3100 ameliorates cigarette smoke-induced emphysema-like manifestations in mice.
American journal of physiology. Lung cellular and molecular physiology. 315(3):L382-L386 [DOI] 10.1152/ajplung.00185.2018. [PMID] 29745251.
2018
Cigarette Smoking Impairs Adipose Stromal Cell Vasculogenic Activity and Abrogates Potency to Ameliorate Ischemia.
Stem cells (Dayton, Ohio). 36(6):856-867 [DOI] 10.1002/stem.2813. [PMID] 29589872.
2018
Hypertension in pregnancy: Taking cues from pathophysiology for clinical practice.
Clinical cardiology. 41(2):220-227 [DOI] 10.1002/clc.22892. [PMID] 29485737.
2018
Rapid clearance of heavy chain-modified hyaluronan during resolving acute lung injury.
Respiratory research. 19(1) [DOI] 10.1186/s12931-018-0812-1. [PMID] 29855321.
2018
Rationale and Design of the CONCERT-HF Trial (Combination of Mesenchymal and c-kit+ Cardiac Stem Cells As Regenerative Therapy for Heart Failure).
Circulation research. 122(12):1703-1715 [DOI] 10.1161/CIRCRESAHA.118.312978. [PMID] 29703749.
2018
Regenerative Medicine in the State of Florida: Letter Outlining the Florida Organization for Regenerative Medicine.
Stem cells translational medicine. 7(7):511-512 [DOI] 10.1002/sctm.18-0066. [PMID] 30403444.
2017
Adipose Stem Cell Function Maintained with Age: An Intra-Subject Study of Long-Term Cryopreserved Cells.
Aesthetic surgery journal. 37(4):454-463 [DOI] 10.1093/asj/sjw197. [PMID] 28364523.
2017
Adipose stromal cells differentiation toward smooth muscle cell phenotype diminishes their vasculogenic activity due to induction of activin A secretion.
Journal of tissue engineering and regenerative medicine. 11(11):3145-3156 [DOI] 10.1002/term.2223. [PMID] 27633499.
2017
Cardiac Cell Therapy Evolving From Complex to Straightforward: Enabling Adoption and Affordability.
Circulation research. 121(10):1116-1118 [DOI] 10.1161/CIRCRESAHA.117.311947. [PMID] 29074527.
2017
Electroacupuncture Promotes Central Nervous System-Dependent Release of Mesenchymal Stem Cells.
Stem cells (Dayton, Ohio). 35(5):1303-1315 [DOI] 10.1002/stem.2613. [PMID] 28299842.
2017
Evaluation of Cell Therapy on Exercise Performance and Limb Perfusion in Peripheral Artery Disease: The CCTRN PACE Trial (Patients With Intermittent Claudication Injected With ALDH Bright Cells).
Circulation. 135(15):1417-1428 [DOI] 10.1161/CIRCULATIONAHA.116.025707. [PMID] 28209728.
2017
Human adipose stromal cell therapy improves survival and reduces renal inflammation and capillary rarefaction in acute kidney injury.
Journal of cellular and molecular medicine. 21(7):1420-1430 [DOI] 10.1111/jcmm.13071. [PMID] 28455887.
2017
Human Adipose-Derived Stem Cells Suppress Elastase-Induced Murine Abdominal Aortic Inflammation and Aneurysm Expansion Through Paracrine Factors.
Cell transplantation. 26(2):173-189 [DOI] 10.3727/096368916X692212. [PMID] 27436185.
2017
Mucosal Perfusion Preservation by a Novel Shapeable Tissue Expander for Oral Reconstruction.
Plastic and reconstructive surgery. Global open. 5(8) [DOI] 10.1097/GOX.0000000000001449. [PMID] 28894668.
2017
Oncostatin M and TNF-α Induce Alpha-1 Antitrypsin Production in Undifferentiated Adipose Stromal Cells.
Stem cells and development. 26(20):1468-1476 [DOI] 10.1089/scd.2017.0099. [PMID] 28825379.
2017
Transcriptional Networks in Single Perivascular Cells Sorted from Human Adipose Tissue Reveal a Hierarchy of Mesenchymal Stem Cells.
Stem cells (Dayton, Ohio). 35(5):1273-1289 [DOI] 10.1002/stem.2599. [PMID] 28233376.
2016
Corrigendum: Adipose-derived Stem Cell Conditioned Media Extends Survival time of a mouse model of Amyotrophic Lateral Sclerosis.
Scientific reports. 6 [DOI] 10.1038/srep20747. [PMID] 27079538.
2016
Distinct Effects of Adipose-Derived Stem Cells and Adipocytes on Normal and Cancer Cell Hierarchy.
Molecular cancer research : MCR. 14(7):660-71 [DOI] 10.1158/1541-7786.MCR-16-0055. [PMID] 27097643.
2016
GDNF secreted from adipose-derived stem cells stimulates VEGF-independent angiogenesis.
Oncotarget. 7(24):36829-36841 [DOI] 10.18632/oncotarget.9208. [PMID] 27167204.
2016
Human Adipose Stromal Cells Increase Survival and Mesenteric Perfusion Following Intestinal Ischemia and Reperfusion Injury.
Shock (Augusta, Ga.). 46(1):75-82 [DOI] 10.1097/SHK.0000000000000571. [PMID] 26796571.
2016
Prospective purification of perivascular presumptive mesenchymal stem cells from human adipose tissue: process optimization and cell population metrics across a large cohort of diverse demographics.
Stem cell research & therapy. 7 [DOI] 10.1186/s13287-016-0302-7. [PMID] 27029948.
2016
Pulmonary Retention of Adipose Stromal Cells Following Intravenous Delivery Is Markedly Altered in the Presence of ARDS.
Cell transplantation. 25(9):1635-1643 [PMID] 26609693.
2016
Surgical Therapies and Tissue Engineering: At the Intersection Between Innovation and Regulation.
Tissue engineering. Part A. 22(5-6):397-400 [DOI] 10.1089/ten.TEA.2016.0002. [PMID] 26895615.
2016
Therapeutic Potential of Adipose-Derived Therapeutic Factor Concentrate for Treating Critical Limb Ischemia.
Cell transplantation. 25(9):1623-1633 [PMID] 26525042.
2015
Adipose Stromal Cell Contact with Endothelial Cells Results in Loss of Complementary Vasculogenic Activity Mediated by Induction of Activin A.
Stem cells (Dayton, Ohio). 33(10):3039-51 [DOI] 10.1002/stem.2074. [PMID] 26037810.
2015
Adipose-derived Stem Cell Conditioned Media Extends Survival time of a mouse model of Amyotrophic Lateral Sclerosis.
Scientific reports. 5 [DOI] 10.1038/srep16953. [PMID] 26586020.
2015
Conditioned media from adipose stromal cells limit lipopolysaccharide-induced lung injury, endothelial hyperpermeability and apoptosis.
Journal of translational medicine. 13 [DOI] 10.1186/s12967-015-0422-3. [PMID] 25889857.
2015
Human adipose-derived stem cells ameliorate cigarette smoke-induced murine myelosuppression via secretion of TSG-6.
Stem cells (Dayton, Ohio). 33(2):468-78 [DOI] 10.1002/stem.1851. [PMID] 25329668.
2015
Intravenous xenogeneic transplantation of human adipose-derived stem cells improves left ventricular function and microvascular integrity in swine myocardial infarction model.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. 86(2):E38-48 [DOI] 10.1002/ccd.25566. [PMID] 24905889.
2014
Adipose stromal cells differentiate along a smooth muscle lineage pathway upon endothelial cell contact via induction of activin A.
Circulation research. 115(9):800-9 [DOI] 10.1161/CIRCRESAHA.115.304026. [PMID] 25114097.
2014
Human adipose-derived stromal/stem cells protect against STZ-induced hyperglycemia: analysis of hASC-derived paracrine effectors.
Stem cells (Dayton, Ohio). 32(7):1831-42 [DOI] 10.1002/stem.1676. [PMID] 24519994.
2014
Intracoronary and retrograde coronary venous myocardial delivery of adipose-derived stem cells in swine infarction lead to transient myocardial trapping with predominant pulmonary redistribution.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. 83(1):E17-25 [DOI] 10.1002/ccd.24659. [PMID] 22972685.
2014
Regenerative therapeutic potential of adipose stromal cells in early stage diabetic retinopathy.
PloS one. 9(1) [DOI] 10.1371/journal.pone.0084671. [PMID] 24416262.
2014
Selective inhibition of pancreatic ductal adenocarcinoma cell growth by the mitotic MPS1 kinase inhibitor NMS-P715.
Molecular cancer therapeutics. 13(2):307-315 [DOI] 10.1158/1535-7163.MCT-13-0324. [PMID] 24282275.
2013
Dr. Sonia Skarlatos-leader, colleague, and friend: from vascular biology to gene therapy and the Cardiovascular Cell Therapy research network.
Human gene therapy. 24(11):896-8 [DOI] 10.1089/hum.2013.2518. [PMID] 24164236.
2013
Intramyocardial transplantation of human adipose-derived stromal cell and endothelial progenitor cell mixture was not superior to individual cell type transplantation in improving left ventricular function in rats with myocardial infarction.
International journal of cardiology. 164(2):205-11 [DOI] 10.1016/j.ijcard.2011.06.128. [PMID] 21794931.
2013
Phase II clinical research design in cardiology: learning the right lessons too well: observations and recommendations from the Cardiovascular Cell Therapy Research Network (CCTRN).
Circulation. 127(15):1630-5 [DOI] 10.1161/CIRCULATIONAHA.112.000779. [PMID] 23588961.
2013
Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal/stem cells: a joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT).
Cytotherapy. 15(6):641-8 [DOI] 10.1016/j.jcyt.2013.02.006. [PMID] 23570660.
2012
Autologous stromal vascular fraction therapy for rheumatoid arthritis: rationale and clinical safety.
International archives of medicine. 5 [DOI] 10.1186/1755-7682-5-5. [PMID] 22313603.
2012
Electroanatomic remodeling of the left stellate ganglion after myocardial infarction.
Journal of the American College of Cardiology. 59(10):954-61 [DOI] 10.1016/j.jacc.2011.11.030. [PMID] 22381432.
2012
Morphologic changes in photodamaged organotypic human skin culture after treatment of autologous adipose-derived stromal cells.
The Journal of craniofacial surgery. 23(3):805-11 [DOI] 10.1097/SCS.0b013e31824e6c87. [PMID] 22565925.
2012
Resident Endothelial Progenitor Cells From Human Placenta Have Greater Vasculogenic Potential Than Circulating Endothelial Progenitor Cells From Umbilical Cord Blood.
Cell medicine. 2(3):85-96 [DOI] 10.3727/215517911X617888. [PMID] 27004134.
2011
Adipose stem cell treatment in mice attenuates lung and systemic injury induced by cigarette smoking.
American journal of respiratory and critical care medicine. 183(2):215-25 [DOI] 10.1164/rccm.201001-0126OC. [PMID] 20709815.
2011
Autologous bone marrow mononuclear cell therapy is safe and promotes amputation-free survival in patients with critical limb ischemia.
Journal of vascular surgery. 53(6):1565-74.e1 [DOI] 10.1016/j.jvs.2011.01.074. [PMID] 21514773.
2011
Potential of gallium-based leads for cardiac rhythm management devices.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2011:341-4 [DOI] 10.1109/IEMBS.2011.6090113. [PMID] 22254318.
2011
The creation of an in vitro adipose tissue that contains a vascular-adipocyte complex.
Biomaterials. 32(36):9667-76 [DOI] 10.1016/j.biomaterials.2011.08.090. [PMID] 21959010.
2010
Adipose tissue progenitor cells directly interact with endothelial cells to induce vascular network formation.
Tissue engineering. Part A. 16(9):2953-66 [PMID] 20486792.
2010
Development of a porcine delayed wound-healing model and its use in testing a novel cell-based therapy.
International journal of radiation oncology, biology, physics. 78(3):888-96 [DOI] 10.1016/j.ijrobp.2010.05.002. [PMID] 20708345.
2010
Muscle-derived Gr1(dim)CD11b(+) cells enhance neovascularization in an ischemic hind limb mouse model.
Blood. 116(9):1623-6 [DOI] 10.1182/blood-2009-08-237040. [PMID] 20516368.
2010
Therapeutic potential of adipose-derived stem cells in vascular growth and tissue repair.
Current opinion in organ transplantation. 15(1):86-91 [DOI] 10.1097/MOT.0b013e328334f074. [PMID] 19949335.
2009
Adipose stromal cells and platelet-rich plasma therapies synergistically increase revascularization during wound healing.
Plastic and reconstructive surgery. 123(2 Suppl):56S-64S [DOI] 10.1097/PRS.0b013e318191be2d. [PMID] 19182664.
2009
Adipose stromal cells-conditional medium protected glutamate-induced CGNs neuronal death by BDNF.
Neuroscience letters. 452(3):238-40 [DOI] 10.1016/j.neulet.2009.01.025. [PMID] 19348731.
2009
Adipose stromal cells-secreted neuroprotective media against neuronal apoptosis.
Neuroscience letters. 462(1):76-9 [DOI] 10.1016/j.neulet.2009.06.054. [PMID] 19549558.
2009
Expression of RAC2 in endothelial cells is required for the postnatal neovascular response.
Experimental cell research. 315(2):248-63 [PMID] 19123268.
2009
IFATS collection: Human adipose tissue-derived stem cells induce angiogenesis and nerve sprouting following myocardial infarction, in conjunction with potent preservation of cardiac function.
Stem cells (Dayton, Ohio). 27(1):230-7 [DOI] 10.1634/stemcells.2008-0273. [PMID] 18772313.
2009
IFATS collection: The conditioned media of adipose stromal cells protect against hypoxia-ischemia-induced brain damage in neonatal rats.
Stem cells (Dayton, Ohio). 27(2):478-88 [DOI] 10.1634/stemcells.2008-0333. [PMID] 19023032.
2009
Interphase FISH demonstrates that human adipose stromal cells maintain a high level of genomic stability in long-term culture.
Stem cells and development. 18(5):717-24 [DOI] 10.1089/scd.2008.0255. [PMID] 18754715.
2009
LifeShirt acquisition system to monitor ECG from ambulatory swine and the implementation of an arrhythmia detection algorithm.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2009:4820-3 [DOI] 10.1109/IEMBS.2009.5332632. [PMID] 19963627.
2009
Robust functional vascular network formation in vivo by cooperation of adipose progenitor and endothelial cells.
Circulation research. 104(12):1410-20 [DOI] 10.1161/CIRCRESAHA.108.190926. [PMID] 19443841.
2009
The human lipodystrophy gene product Berardinelli-Seip congenital lipodystrophy 2/seipin plays a key role in adipocyte differentiation.
Endocrinology. 150(10):4552-61 [DOI] 10.1210/en.2009-0236. [PMID] 19574402.
2009
White adipose tissue cells are recruited by experimental tumors and promote cancer progression in mouse models.
Cancer research. 69(12):5259-66 [DOI] 10.1158/0008-5472.CAN-08-3444. [PMID] 19491274.
2008
A central role for hepatocyte growth factor in adipose tissue angiogenesis.
American journal of physiology. Endocrinology and metabolism. 294(2):E336-44 [PMID] 18073323.
2008
A population of multipotent CD34-positive adipose stromal cells share pericyte and mesenchymal surface markers, reside in a periendothelial location, and stabilize endothelial networks.
Circulation research. 102(1):77-85 [PMID] 17967785.
2008
Adipose stromal/stem cells: basic and translational advances: the IFATS collection.
Stem cells (Dayton, Ohio). 26(10):2664-5 [DOI] 10.1634/stemcells.2008-0927. [PMID] 18818434.
2008
Coronary venous retroperfusion: an old concept, a new approach.
Journal of applied physiology (Bethesda, Md. : 1985). 104(5):1266-72 [DOI] 10.1152/japplphysiol.00063.2008. [PMID] 18292303.
2008
IFATS collection: Adipose stromal cell differentiation is reduced by endothelial cell contact and paracrine communication: role of canonical Wnt signaling.
Stem cells (Dayton, Ohio). 26(10):2674-81 [DOI] 10.1634/stemcells.2008-0277. [PMID] 18669909.
2008
IFATS collection: Combinatorial peptides identify alpha5beta1 integrin as a receptor for the matricellular protein SPARC on adipose stromal cells.
Stem cells (Dayton, Ohio). 26(10):2735-45 [DOI] 10.1634/stemcells.2008-0212. [PMID] 18583538.
2008
In vitro clonal analysis of murine pluripotent stem cells isolated from skeletal muscle and adipose stromal cells.
Experimental hematology. 36(2):224-34 [PMID] 18023524.
2008
Transgenic model of smooth muscle cell cycle reentry: expression pattern of the collageneous matrix.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. 17(2):72-80 [DOI] 10.1016/j.carpath.2007.07.003. [PMID] 18329551.
2007
Acute myocardial infarction in swine rapidly and selectively releases highly proliferative endothelial colony forming cells (ECFCs) into circulation.
Cell transplantation. 16(9):887-97 [PMID] 18293887.
2007
Suppression of hepatocyte growth factor production impairs the ability of adipose-derived stem cells to promote ischemic tissue revascularization.
Stem cells (Dayton, Ohio). 25(12):3234-43 [PMID] 17901400.
2007
Urokinase gene transfer augments angiogenesis in ischemic skeletal and myocardial muscle.
Molecular therapy : the journal of the American Society of Gene Therapy. 15(11):1939-46 [PMID] 17653104.
2006
[Adipose stromal cells–plastic type of cells with high therapeutic potential].
Tsitologiia. 48(2):83-94 [PMID] 16737175.
2006
[Adipose tissue stromal cells — multipotent cells with therapeutic potential for stimulation of angiogenesis in tissue ischemia].
Kardiologiia. 46(6):53-63 [PMID] 16883224.
2006
Adipose tissue production of hepatocyte growth factor contributes to elevated serum HGF in obesity.
American journal of physiology. Endocrinology and metabolism. 291(4):E843-8 [PMID] 16757549.
2006
Endothelial-monocyte-activating polypeptide II induces migration of endothelial progenitor cells via the chemokine receptor CXCR3.
Experimental hematology. 34(8):1125-32 [PMID] 16863920.
2006
Vascular injury response in mice is dependent on genetic background.
American journal of physiology. Heart and circulatory physiology. 290(3):H1307-10 [PMID] 16214836.
2005
Angiostatin is negatively associated with coronary collateral growth in patients with coronary artery disease.
American journal of physiology. Heart and circulatory physiology. 288(5):H2042-6 [PMID] 15840902.
2005
Balancing luminal size and smooth muscle proliferation–a key control point in atherosclerosis and arteriogenesis.
EXS. (94):193-205 [PMID] 15617480.
2005
Clonal multilineage differentiation of murine common pluripotent stem cells isolated from skeletal muscle and adipose stromal cells.
Annals of the New York Academy of Sciences. 1044:183-200 [PMID] 15958712.
2005
Enhancing myocardial plasmid expression by retrograde coronary venous delivery.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. 65(4):528-34 [PMID] 16003788.
2005
Radiolabeled cell distribution after intramyocardial, intracoronary, and interstitial retrograde coronary venous delivery: implications for current clinical trials.
Circulation. 112(9 Suppl):I150-6 [PMID] 16159808.
2005
Stent-based nitric oxide delivery reducing neointimal proliferation in a porcine carotid overstretch injury model.
Cardiovascular and interventional radiology. 28(1):60-5 [PMID] 15719180.
2004
Cellular approaches to tissue repair in cardiovascular disease: the more we know, the more there is to learn.
American journal of physiology. Heart and circulatory physiology. 287(2):H458-63 [PMID] 15277189.
2004
Engineered zinc finger-activating vascular endothelial growth factor transcription factor plasmid DNA induces therapeutic angiogenesis in rabbits with hindlimb ischemia.
Circulation. 110(16):2467-75 [PMID] 15477407.
2004
Exercise acutely increases circulating endothelial progenitor cells and monocyte-/macrophage-derived angiogenic cells.
Journal of the American College of Cardiology. 43(12):2314-8 [PMID] 15193699.
2004
P38 MAPK mediates myocardial proinflammatory cytokine production and endotoxin-induced contractile suppression.
Shock (Augusta, Ga.). 21(2):170-4 [PMID] 14752292.
2004
Preconditioning: evolution of basic mechanisms to potential therapeutic strategies.
Shock (Augusta, Ga.). 21(3):195-209 [PMID] 14770032.
2004
Reduced pericardial levels of endostatin correlate with collateral development in patients with ischemic heart disease.
Journal of the American College of Cardiology. 43(8):1383-7 [PMID] 15093871.
2004
Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells.
Circulation. 109(10):1292-8 [PMID] 14993122.
2003
A novel percutaneous technique for accessing the normal pericardium: a single-center successful experience of 53 porcine procedures.
The Journal of invasive cardiology. 15(1):13-7 [PMID] 12499522.
2003
From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I.
Circulation. 108(14):1664-72 [PMID] 14530185.
2003
From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part II.
Circulation. 108(15):1772-8 [PMID] 14557340.
2003
Intrapericardial ethanol delivery inhibits neointimal proliferation after porcine coronary overstretch.
Journal of the Chinese Medical Association : JCMA. 66(11):637-42 [PMID] 14768850.
2003
Obesity is associated with increased levels of circulating hepatocyte growth factor.
Journal of the American College of Cardiology. 41(8):1408-13 [PMID] 12706940.
2003
Peripheral blood “endothelial progenitor cells” are derived from monocyte/macrophages and secrete angiogenic growth factors.
Circulation. 107(8):1164-9 [PMID] 12615796.
2003
Role of pRb family members in injured carotid arteries.
Journal of vascular research. 40(1):83-4 [PMID] 12644729.
2003
Vascular ligation response is independent of p107: stressing the role of the related p130.
American journal of physiology. Heart and circulatory physiology. 285(2):H915-8 [PMID] 12860570.
2003
Widespread regional myocardial transfection by plasmid encoding Del-1 following retrograde coronary venous delivery.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. 58(2):207-11 [PMID] 12552546.
2002
Direct evidence for the importance of p130 in injury response and arterial remodeling following carotid artery ligation.
Cardiovascular research. 54(3):676-83 [PMID] 12031714.
2001
Improved laser-assisted vascular tissue fusion using light-activated surgical adhesive in a porcine model.
Biomedical sciences instrumentation. 37:451-6 [PMID] 11347433.
2001
Liquid-filled balloon brachytherapy using (68)Ga is effective and safe because of the short 68-minute half-life: results of a feasibility study in the porcine coronary overstretch model.
Circulation. 103(13):1793-8 [PMID] 11282912.
2000
Differences in the effects of HMG-CoA reductase inhibitors on proliferation and viability of smooth muscle cells in culture.
Atherosclerosis. 150(2):331-41 [PMID] 10856525.
2000
Intrapericardial paclitaxel delivery inhibits neointimal proliferation and promotes arterial enlargement after porcine coronary overstretch.
Circulation. 102(13):1575-81 [PMID] 11004150.
2000
Studies of renal injury III: lipid-induced nephropathy in type II diabetes.
Kidney international. 57(1):92-104 [PMID] 10620191.
1999
Efficient in vivo catheter-based pericardial gene transfer mediated by adenoviral vectors.
Clinical cardiology. 22(1 Suppl 1):I23-9 [PMID] 9929764.
1999
Establishment of a clinically correlated human pericardial fluid bank: evaluation of intrapericardial diagnostic potential.
Clinical cardiology. 22(1 Suppl 1):I40-2 [PMID] 9929767.
1999
Hyperplasia in multiple smooth muscle tissues in transgenic mice expressing a temperature-sensitive SV40 T-antigen under the control of smooth muscle alpha-actin regulatory sequences.
Oncogene. 18(25):3773-82 [PMID] 10391686.
1999
NGF activates similar intracellular signaling pathways in vascular smooth muscle cells as PDGF-BB but elicits different biological responses.
Arteriosclerosis, thrombosis, and vascular biology. 19(4):1041-50 [PMID] 10195934.
1999
Pharmacokinetics and consistency of pericardial delivery directed to coronary arteries: direct comparison with endoluminal delivery.
Clinical cardiology. 22(1 Suppl 1):I10-6 [PMID] 9929762.
1998
Gene therapy for restenosis: getting nearer the heart of the matter.
Circulation research. 82(3):295-305 [PMID] 9486657.
1998
Heparin responsiveness in vitro as a prognostic tool for vascular graft stenosis: a tale of two cell types?
Circulation. 97(25):2486-90 [PMID] 9657465.
1997
Activation of MAP kinase in vivo follows balloon overstretch injury of porcine coronary and carotid arteries.
Circulation research. 81(6):904-10 [PMID] 9400370.
1997
Effect of atherosclerosis on transmural convection an arterial ultrastructure. Implications for local intravascular drug delivery.
Arteriosclerosis, thrombosis, and vascular biology. 17(12):3365-75 [PMID] 9437181.
1996
Human surfactant protein A enhances attachment of Pneumocystis carinii to rat alveolar macrophages.
American journal of respiratory cell and molecular biology. 14(3):232-8 [PMID] 8845173.
1996
Methods of local gene delivery to vascular tissues.
Seminars in interventional cardiology : SIIC. 1(3):215-23 [PMID] 9552514.
1996
Microparticle deposition in periarterial microvasculature and intramural dissections after porous balloon delivery into atherosclerotic vessels: quantitation and localization by confocal scanning laser microscopy.
American heart journal. 131(5):892-8 [PMID] 8615307.
1996
Microspheres.
Seminars in interventional cardiology : SIIC. 1(1):48-50 [PMID] 9552493.
1996
Vascular repair mechanisms after directional atherectomy or percutaneous transluminal coronary angioplasty in atherosclerotic rabbit iliac arteries.
American heart journal. 132(1 Pt 1):13-22 [PMID] 8701854.
1995
Local delivery of biodegradable microparticles containing colchicine or a colchicine analogue: effects on restenosis and implications for catheter-based drug delivery.
Journal of the American College of Cardiology. 26(6):1549-57 [PMID] 7594084.
1995
Pharmacokinetics of adenoviral vector-mediated gene delivery to vascular smooth muscle cells: modulation by poloxamer 407 and implications for cardiovascular gene therapy.
Human gene therapy. 6(1):41-53 [PMID] 7703286.
1995
Regional and arterial localization of radioactive microparticles after local delivery by unsupported or supported porous balloon catheters.
American heart journal. 129(5):852-9 [PMID] 7732972.
1995
Vascular injury, repair, and restenosis after percutaneous transluminal angioplasty in the atherosclerotic rabbit.
Circulation. 92(10):2995-3005 [PMID] 7586270.
1994
Biodegradable microspheres containing a colchicine analogue inhibit DNA synthesis in vascular smooth muscle cells.
Circulation. 89(5):1929-33 [PMID] 8181114.
1993
8-Methoxypsoralen and longwave ultraviolet irradiation are a novel antiproliferative combination for vascular smooth muscle.
Circulation. 87(1):184-91 [PMID] 8419006.
1993
Effects of thiol protease inhibitors on cell cycle and proliferation of vascular smooth muscle cells in culture.
Circulation research. 72(2):413-23 [PMID] 8418992.
1993
Methods and devices for local drug delivery in coronary and peripheral arteries.
Trends in cardiovascular medicine. 3(5):163-70 [DOI] 10.1016/1050-1738(93)90001-M. [PMID] 21244928.
1991
Direct intraarterial wall injection of microparticles via a catheter: a potential drug delivery strategy following angioplasty.
American heart journal. 122(4 Pt 1):1136-40 [PMID] 1833964.
1991
Vascular smooth muscle. A review of the molecular basis of contractility.
Circulation. 83(2):382-90 [PMID] 1991362.
1989
Current concepts of left ventricular pseudoaneurysm: pathophysiology, therapy, and diagnostic imaging methods.
Clinical cardiology. 12(9):531-40 [PMID] 2676292.
1989
Molecular cardiology: new avenues for the diagnosis and treatment of cardiovascular disease.
Journal of the American College of Cardiology. 13(2):265-82 [PMID] 2643653.
1986
Effects of intraoperative glucose on protein catabolism and plasma glucose levels in patients with supratentorial tumors.
Anesthesiology. 64(4):453-9 [PMID] 3516017.

Grants

Jan 2024 ACTIVE
A Phase 1, Open label, Dose-ranging Study to Assess the Safety, Tolerability, Preliminary Efficacy, and Dose Effect of CFL001 Cord Blood Product in Patients with Symptomatic Sacroiliac Joint (SIJ) Syndrome – Services Agreement
Role: Principal Investigator
Funding: CORD FOR LIFE
Jul 2023 ACTIVE
Sex differences in novel viral myocarditis therapeutic: adipose-derived stem cell secretome
Role: Other
Funding: AMER HEART ASSOCIATION
Jul 2023 ACTIVE
IPA – Functional and Mechanistic Analysis of Mesenchymal Stem Seretome to Ameliorate Ischemic Damage of Rodent Hearts in situ and Human Myocardium-on-a-Chip
Role: Other
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
Dec 2020 – Nov 2021
IPA for Stephanie Merfeld-Clauss
Role: Other
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
Mar 2019 – Feb 2022
Combination of Secretome from Electrically Stimulated ASCs and Injectable ECM Scaffolds as Potential SCI Therapy
Role: Project Manager
Funding: NATL INST OF HLTH NINDS
Jan 2019 – Jun 2021
Miscellaneous Donors Project
Role: Principal Investigator
Funding: MISCELLANEOUS DONORS
Dec 2018 – Nov 2020
IPA for Stephanie Merfeld-Clauss
Role: Other
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
Sep 2018 – Jul 2023
An integrated human organ-on-chip ultrasensitive miRNA detection platform for novel biomarker discovery
Role: Principal Investigator
Funding: UNIV OF NOTRE DAME via NATL INST OF HLTH NHLBI
Jun 2018 – May 2021
OR-DRPD-ROF2018: Perfusable Magnetic Cryoprotecting Agents for Heart Biobanking
Role: Co-Investigator
Funding: UF RESEARCH
Sep 2017 ACTIVE
Women's Ischemia Trial to Reduce Events in Non-Obstructive CAD (WARRIOR)
Role: Project Manager
Funding: US ARMY MED RES ACQUISITION
Jul 2017 – Jun 2019
Adipose Stem Cell Secretome Provides Novel Functional and Molecular Cardiac Preservation
Role: Principal Investigator
Funding: AMER HEART ASSOCIATION

Contact Details

Phones:
Business:
(352) 294-8620
Emails:
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PO Box 100288
GAINESVILLE FL 32610