William M Miles

William M Miles, MD, FACC

Professor

Department: MD-CARDIOLOGY
Business Phone: (352) 265-0820

About William M Miles

Dr. William Miles is Professor of Medicine and Silverstein Chair for Cardiovascular Education. He joined the faculty at the University of Florida in 2005. Prior to his current appointment, he was on the faculty at Indiana University from 1983-1998 where he was Professor of Medicine and Director of the Electrophysiology Laboratory. In 1998, he joined a cardiology/electrophysiology practice in Fort Myers, Florida, but remained active in teaching as Voluntary Professor of Medicine at the University of Miami. He is certified in Clinical Cardiac Electrophysiology by the American Board of Internal Medicine. He is a Fellow of American College of Cardiology and the Heart Rhythm Society. He is Program Director for the UF Clinical Cardiac Electrophysiology Training Program.

Board Certifications

  • Cardiovascular Disease
    American Board of Internal Medicine
  • Clinical Cardiac Electrophysiology
    American Board of Internal Medicine
  • Internal Medicine
    American Board of Internal Medicine

Clinical Profile

Specialties
  • Cardiology
Subspecialties
  • Cardiovascular Disease
  • Clinical Cardiac Electrophysiology
Areas of Interest
  • Arrhythmias
  • Atrial fibrillation or flutter
  • Heart pacemaker
  • Implantable cardioverter-defibrillator

Publications

2022
Rate-dependent change in capture threshold following implantation of a leadless pacemaker.
HeartRhythm case reports. 8(3):183-186 [DOI] 10.1016/j.hrcr.2021.12.004. [PMID] 35492834.
2022
The ICD calls it VT but points out to a different diagnosis!
Pacing and clinical electrophysiology : PACE. 45(1):145-148 [DOI] 10.1111/pace.14426. [PMID] 34893988.
2022
Treating Obstructive Sleep Apnea and Atrial Fibrillation: Focus on Substrate, Triggers, and Those Evasive Outcomes.
JACC. Clinical electrophysiology. 8(7):878-881 [DOI] 10.1016/j.jacep.2022.06.001. [PMID] 35863813.
2022
Why is the patient still symptomatic after myectomy for HCM!
Pacing and clinical electrophysiology : PACE. 45(10):1207-1209 [DOI] 10.1111/pace.14567. [PMID] 35841613.
2022
Workup for Suspected Brugada Syndrome: Two Case Reports for the General Practitioner.
Cureus. 14(2) [DOI] 10.7759/cureus.21921. [PMID] 35273866.
2021
Analysis of P-Wave Morphology Is Not Passé in This Era of High-Definition Electroanatomic Mapping.
JACC. Clinical electrophysiology. 7(12):1557-1560 [DOI] 10.1016/j.jacep.2021.09.018. [PMID] 34949423.
2021
Erratum to “Cardiovascular Considerations for the Internist and Hospitalist in the COVID-19 Era” AmJMed, 133(11); 1254-1261.
The American journal of medicine. 134(4) [DOI] 10.1016/j.amjmed.2021.01.001. [PMID] 33461734.
2021
Massive Tension Hemothorax After Pacemaker Implantation.
Cureus. 13(7) [DOI] 10.7759/cureus.16754. [PMID] 34513377.
2021
Physiologic Variants of Cardiac Conduction (Aberration, Gap, Supernormal Conduction).
Cardiac electrophysiology clinics. 13(4):607-624 [DOI] 10.1016/j.ccep.2021.07.002. [PMID] 34689890.
2020
Cardiovascular Considerations for the Internist and Hospitalist in the COVID-19 Era.
The American journal of medicine. 133(11):1254-1261 [DOI] 10.1016/j.amjmed.2020.06.005. [PMID] 32653420.
2019
Minimally invasive thoracoscopic surgery is an effective approach for treating inappropriate sinus tachycardia.
Journal of cardiovascular electrophysiology. 30(8):1297-1303 [DOI] 10.1111/jce.13970. [PMID] 31222889.
2018
Iatrogenic Ventricular Fibrillation after Direct-Current Cardioversion of Preexcited Atrial Fibrillation Caused by Inadvertent T-Wave Synchronization.
Texas Heart Institute journal. 45(1):39-41 [DOI] 10.14503/THIJ-16-6162. [PMID] 29556151.
2018
Meta-Analysis Comparing Catheter-Guided Ablation Versus Conventional Medical Therapy for Patients With Atrial Fibrillation and Heart Failure With Reduced Ejection Fraction.
The American journal of cardiology. 122(5):806-813 [DOI] 10.1016/j.amjcard.2018.05.009. [PMID] 30037427.
2017
Atrial Fibrillation Ablation Increases Inflammation-Chemokine Modulation Suppresses Activation of Leukocytes Isolated after Ablation.
Cardiovascular & hematological disorders drug targets. 17(3):195-204 [DOI] 10.2174/1871529X17666170918140442. [PMID] 28925907.
2016
An Unusual Atrial Tachycardia in a Cardiac Transplant Patient.
Journal of cardiovascular electrophysiology. 27(7):878-80 [DOI] 10.1111/jce.12922. [PMID] 26756831.
2016
Subcutaneous ICD implant complicated by an intraperitoneal lead course and device infection.
HeartRhythm case reports. 2(3):270-271 [DOI] 10.1016/j.hrcr.2016.01.001. [PMID] 28491687.
2016
Thoracoscopic Ablation With Appendage Ligation Versus Medical Therapy for Stroke Prevention: A Proof-of-Concept Randomized Trial.
Innovations (Philadelphia, Pa.). 11(2):99-105 [DOI] 10.1097/IMI.0000000000000226. [PMID] 26914668.
2010
Detection of a retention wire fracture in an asymptomatic patient 18 years after implantation.
Pacing and clinical electrophysiology : PACE. 33(2):246-7 [DOI] 10.1111/j.1540-8159.2009.02533.x. [PMID] 19744272.
2010
Lead astray: minimally invasive removal of a pacing lead in the left ventricle.
Clinical cardiology. 33(6):E109-10 [DOI] 10.1002/clc.20728. [PMID] 20552628.
2010
Minimally invasive ablation of a migrating focus of inappropriate sinus tachycardia.
The Journal of thoracic and cardiovascular surgery. 139(2):506-7 [DOI] 10.1016/j.jtcvs.2009.01.002. [PMID] 19660289.
2009
Appropriate evaluation and treatment of heart failure patients after implantable cardioverter-defibrillator discharge: time to go beyond the initial shock.
Journal of the American College of Cardiology. 54(22):1993-2000 [DOI] 10.1016/j.jacc.2009.07.039. [PMID] 19926003.
2009
Benefit of cardiac resynchronization in elderly patients: results from the Multicenter InSync Randomized Clinical Evaluation (MIRACLE) and Multicenter InSync ICD Randomized Clinical Evaluation (MIRACLE-ICD) trials.
Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing. 25(2):91-6 [DOI] 10.1007/s10840-008-9330-2. [PMID] 19152106.
2008
Acute and long-term efficacy and safety of catheter cryoablation of the cavotricuspid isthmus for treatment of type 1 atrial flutter.
Heart rhythm. 5(7):1009-14 [DOI] 10.1016/j.hrthm.2008.03.019. [PMID] 18598956.
2007
Patient evaluation of ICD recall communication strategies: a vignette study.
Pacing and clinical electrophysiology : PACE. 30(9):1105-11 [PMID] 17725753.
2007
Successful termination of atrial flutter by ibutilide during pregnancy.
Pacing and clinical electrophysiology : PACE. 30(2):283-6 [PMID] 17338730.
2001
Idiopathic ventricular outflow tract tachycardia: where does it originate?
Journal of cardiovascular electrophysiology. 12(5):536-7 [PMID] 11386513.
2000
Ventricular tachycardias mimicking those arising from the right ventricular outflow tract.
Journal of cardiovascular electrophysiology. 11(1):45-51 [PMID] 10695461.
1999
Interactions between electronic article surveillance systems and implantable cardioverter-defibrillators.
Circulation. 100(4):387-92 [PMID] 10421599.
1998
Phenylephrine increases T wave shock energy required to induce ventricular fibrillation.
Journal of cardiovascular electrophysiology. 9(1):34-40 [PMID] 9475575.
1998
Short-term rapid ventricular pacing prolongs ventricular refractoriness in patients.
Journal of cardiovascular electrophysiology. 9(10):1036-42 [PMID] 9817555.
1996
Defibrillation shocks over epicardial patches produce sympathetic neural dysfunction in man.
Journal of cardiovascular electrophysiology. 7(5):398-405 [PMID] 8722585.
1995
Ablative therapy for ventricular arrhythmias.
Progress in cardiovascular diseases. 37(4):225-42 [PMID] 7831468.
1995
Spontaneous echo contrast following delivery of a shock from a transvenous implantable cardioverter defibrillator.
Journal of cardiovascular electrophysiology. 6(5):396-9 [PMID] 7551309.
1994
Elimination of AV nodal reentrant tachycardia with 2:1 VA block by posteroseptal ablation.
Journal of cardiovascular electrophysiology. 5(6):510-6 [PMID] 8087295.
1994
Multiple accessory pathways in the permanent form of junctional reciprocating tachycardia.
The American journal of cardiology. 73(5):361-7 [PMID] 8109550.
1993
Bundle branch reentrant tachycardia: a chance to cure?
Journal of cardiovascular electrophysiology. 4(3):263-5 [PMID] 8269298.
1993
Differential effects of isoproterenol on sustained ventricular tachycardia before and during procainamide and quinidine antiarrhythmic drug therapy.
Circulation. 87(3):783-92 [PMID] 8443899.
1993
Five-year follow-up of 589 patients treated with amiodarone.
American heart journal. 125(1):109-20 [PMID] 8417505.
1993
Radiofrequency ablation for atrioventricular node reentrant tachycardia: comparison between fast (anterior) and slow (posterior) pathway ablation.
Journal of the American College of Cardiology. 21(2):432-41 [PMID] 8426009.
1993
Regional cardiac sympathetic denervation in patients with ventricular tachycardia in the absence of coronary artery disease.
Journal of the American College of Cardiology. 22(5):1344-53 [PMID] 8227790.
1992
Catheter ablation of ventricular tachycardia using radiofrequency techniques in patients without structural heart disease.
Herz. 17(3):179-89 [PMID] 1639337.
1992
Radiofrequency catheter ablation of ventricular tachycardia in patients without structural heart disease.
Circulation. 85(5):1666-74 [PMID] 1572025.
1992
Surgery for atrioventricular node reentry tachycardia. Results with surgical skeletonization of the atrioventricular node and discrete perinodal cryosurgery.
The Journal of thoracic and cardiovascular surgery. 104(4):1035-44 [PMID] 1405661.
1991
Antitachycardia devices: realities and promises.
Journal of the American College of Cardiology. 18(5):1349-62 [PMID] 1918713.
1990
Effect of atrioventricular interval during pacing or reciprocating tachycardia on atrial size, pressure, and refractory period. Contraction-excitation feedback in human atrium.
Circulation. 82(1):60-8 [PMID] 2364525.
1989
Arrhythmogenic effects of antiarrhythmic drugs: a study of 506 patients treated for ventricular tachycardia or fibrillation.
Journal of the American College of Cardiology. 14(1):209-15; discussion 216 [PMID] 2738263.
1989
Regional sympathetic denervation after myocardial infarction in humans detected noninvasively using I-123-metaiodobenzylguanidine.
Journal of the American College of Cardiology. 14(6):1519-26 [PMID] 2809013.
1989
The electrophysiologic effects of enoximone in patients with preexisting ventricular tachyarrhythmias.
American heart journal. 117(1):112-21 [PMID] 2521415.
1988
Clinical characteristics of patients with ventricular fibrillation during antiarrhythmic drug therapy.
The New England journal of medicine. 319(5):257-62 [PMID] 3393179.
1988
Encainide for atrial fibrillation associated with Wolff-Parkinson-White syndrome.
The American journal of cardiology. 62(19):26L-30L [PMID] 3144164.
1988
Encainide for treatment of atrioventricular reciprocating tachycardia in the Wolff-Parkinson-White syndrome.
The American journal of cardiology. 62(19):20L-25L [PMID] 3144163.
1988
Parasympathetic and sympathetic alterations of Mobitz type II heart block.
Journal of the American College of Cardiology. 11(2):271-5 [PMID] 3339166.
1988
Prospective evaluation of a discriminant function for prediction of recurrent symptomatic ventricular tachycardia or ventricular fibrillation in coronary artery disease patients receiving amiodarone and having inducible ventricular tachycardia at electrophysiologic study.
The American journal of cardiology. 61(13):1024-30 [PMID] 3364357.
1988
Surgical division of Wolff-Parkinson-White pathways utilizing the closed-heart technique: a 2-year experience in 47 patients.
The Annals of thoracic surgery. 45(5):495-504 [PMID] 3365040.
1988
Transcutaneous pacing: patient tolerance, strength-interval relations and feasibility for programmed electrical stimulation.
The American journal of cardiology. 62(16):1126-9 [PMID] 3189176.
1987
Electrophysiologic and antiarrhythmic effects of oral encainide in patients with atrioventricular nodal reentry or nodoventricular reentry.
American heart journal. 114(1 Pt 1):26-33 [PMID] 3111237.
1987
Pharmacokinetic and electrophysiologic interactions of amiodarone and procainamide.
Clinical pharmacology and therapeutics. 41(6):603-10 [PMID] 3581646.
1987
Supernormal conduction in accessory atrioventricular connections.
The American journal of cardiology. 59(8):852-6 [PMID] 3825949.
1987
Two retrograde atrial responses from one ventricular complex in the permanent form of junctional reciprocating tachycardia.
The American journal of cardiology. 59(9):1004-6 [PMID] 2436467.
1986
Alteration of human right bundle branch refractoriness by changes in duration of the atrial drive train.
Circulation. 73(2):244-8 [PMID] 3943159.
1986
Clinical experience with amiodarone for treatment of recurrent ventricular tachycardia and ventricular fibrillation.
British journal of clinical practice. Supplement. 44:16-27 [PMID] 3089256.
1986
Determination of the earliest site of ventricular activation in Wolff-Parkinson-White syndrome: application of digital continuous loop two-dimensional echocardiography.
Journal of the American College of Cardiology. 7(6):1286-94 [PMID] 3711485.
1986
Encainide for treatment of supraventricular tachycardias associated with the Wolff-Parkinson-White syndrome.
The American journal of cardiology. 58(5):41C-48C [PMID] 3092619.
1986
Subthreshold conditioning stimuli prolong human ventricular refractoriness.
The American journal of cardiology. 57(6):381-6 [PMID] 3946251.
1986
Supraventricular tachycardia in patients without overt preexcitation.
Cardiology clinics. 4(3):429-46 [PMID] 3530466.
1986
Survivors of cardiac arrest: prevention of recurrence by drug therapy as predicted by electrophysiologic testing or electrocardiographic monitoring.
The American journal of cardiology. 57(1):113-9 [PMID] 3942053.
1986
The implantable transvenous cardioverter: long-term efficacy and reproducible induction of ventricular tachycardia.
Circulation. 74(3):518-24 [PMID] 3742753.
1986
The preexcitation index: an aid in determining the mechanism of supraventricular tachycardia and localizing accessory pathways.
Circulation. 74(3):493-500 [PMID] 3742751.
1984
Antiarrhythmic and electrophysiologic effects of oral propafenone.
The American journal of cardiology. 54(9):26D-28D [PMID] 6496366.
1984
Clinical use and pharmacology of amiodarone.
The Medical clinics of North America. 68(5):1339-66 [PMID] 6387328.
1984
Development of the implantable transvenous cardioverter.
The American journal of cardiology. 54(9):67D-72D [PMID] 6496370.
1984
Early experience with an implantable cardioverter.
The New England journal of medicine. 311(8):485-90 [PMID] 6749205.
1984
Evaluation of the patient with wide QRS tachycardia.
The Medical clinics of North America. 68(5):1015-38 [PMID] 6492929.
1984
Future directions: electrical therapy for cardiac tachyarrhythmias.
Pacing and clinical electrophysiology : PACE. 7(3 Pt 2):606-10 [PMID] 6204321.
1984
Initial experience with Symbios Model 7008 pacemaker.
Pacing and clinical electrophysiology : PACE. 7(6 Pt 2):1301-5 [PMID] 6209674.
1984
Preexcitation syndromes. Mechanisms and management.
The Medical clinics of North America. 68(4):831-93 [PMID] 6381927.
1984
Preliminary experience with the implantable transvenous cardioverter.
Pacing and clinical electrophysiology : PACE. 7(6 Pt 2):1325-30 [PMID] 6209678.
1984
Propafenone treatment of recurrent ventricular tachycardia: comparison of continuous electrocardiographic recording and electrophysiologic study in predicting drug efficacy.
The American journal of cardiology. 54(9):40D-44D [PMID] 6496368.
1984
Synchronous intracardiac cardioversion.
Pacing and clinical electrophysiology : PACE. 7(3 Pt 2):522-33 [PMID] 6204310.
1982
Deceleration-dependent left bundle branch block: a spectrum of bundle branch conduction delay.
Circulation. 65(5):1029-32 [PMID] 7074740.

Grants

Mar 2021 ACTIVE
SyncAV Post-Market Trial
Role: Principal Investigator
Funding: ABBOTT LABORATORIES
May 2016 – Nov 2020
OPTIMUM LEAD INSULATION MATERIAL REGISTRY
Role: Principal Investigator
Funding: ST JUDE MEDICAL CENTER
May 2016 – Feb 2019
SUSTAINED TREATMENT OF PAROXYSMAL ATRIAL FIBRILLATION POST-APPROVAL STUDY (STOP AF PAS)
Role: Principal Investigator
Funding: MEDTRONIC INC
Feb 2014 ACTIVE
MILES PAYROLL OPERATING PROJECT
Role: Principal Investigator
Funding: 214 OPERATING ACCOUNT
Sep 2012 – Feb 2019
Sustained Treatment of Paroxysmal Atrial Fibrillation Post-Approval Study (STOP AF PAS)
Role: Principal Investigator
Funding: MEDTRONIC INC
Nov 2008 – Dec 2019
Vest prevention of Early Sudden Death Trial (VEST) and PREDiction of ICD Therapies Study (PREDICTS)
Role: Principal Investigator
Funding: UNIV OF CALIFORNIA SAN FRANCISCO via NATL INST OF HLTH NHLBI
Nov 2006 – Nov 2018
OPTIMUM Lead Insulation Material Registry
Role: Principal Investigator
Funding: ST JUDE MEDICAL CENTER
Jul 2004 – Oct 2020
Advanced Training Clinical Fellowship Program
Role: Project Manager
Funding: MULTIPLE SPONSORS

Education

Fellowship – Cardiovascular Disease
1983 · Indiana University Hospital
Residency – Internal Medicine
1980 · Medical College of Virginia
Internship – Internal Medicine
1978 · Medical College of Virginia
Medical Degree
1977 · Medical College of Virginia

Contact Details

Phones:
Business:
(352) 265-0820
Emails:
Addresses:
Business Mailing:
PO BOX 100277
DEPT OF MEDICINE
GAINESVILLE FL 326100277
Business Street:
1600 SW ARCHER RD
GAINESVILLE FL 32610