Identifying Cancer Patients at Risk for Heart Failure Using Machine Learning Methods.
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Adipose-derived stem cell conditioned medium impacts asymptomatic peripheral neuromuscular denervation in the mutant superoxide dismutase (G93A) transgenic mouse model of amyotrophic lateral sclerosis.
Restorative neurology and neuroscience. 36(5):621-627 [DOI] 10.3233/RNN-180820. [PMID] 30010155.
Evaluation of Cell Therapy on Exercise Performance and Limb Perfusion in Peripheral Artery Disease: The CCTRN PACE Trial (Patients With Intermittent Claudication Injected With ALDH Bright Cells).
Circulation. 135(15):1417-1428 [DOI] 10.1161/CIRCULATIONAHA.116.025707. [PMID] 28209728.
Adipose stromal cells differentiation toward smooth muscle cell phenotype diminishes their vasculogenic activity due to induction of activin A secretion.
Journal of tissue engineering and regenerative medicine. 11(11):3145-3156 [DOI] 10.1002/term.2223. [PMID] 27633499.
Therapeutic Potential of Adipose-Derived Therapeutic Factor Concentrate for Treating Critical Limb Ischemia.
Cell transplantation. 25(9):1623-1633 [PMID] 26525042.
Prospective purification of perivascular presumptive mesenchymal stem cells from human adipose tissue: process optimization and cell population metrics across a large cohort of diverse demographics.
Stem cell research & therapy. 7 [DOI] 10.1186/s13287-016-0302-7. [PMID] 27029948.
Pulmonary Retention of Adipose Stromal Cells Following Intravenous Delivery Is Markedly Altered in the Presence of ARDS.
Cell transplantation. 25(9):1635-1643 [PMID] 26609693.
Intravenous xenogeneic transplantation of human adipose-derived stem cells improves left ventricular function and microvascular integrity in swine myocardial infarction model.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. 86(2):E38-48 [DOI] 10.1002/ccd.25566. [PMID] 24905889.
Intracoronary and retrograde coronary venous myocardial delivery of adipose-derived stem cells in swine infarction lead to transient myocardial trapping with predominant pulmonary redistribution.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. 83(1):E17-25 [DOI] 10.1002/ccd.24659. [PMID] 22972685.
Intramyocardial transplantation of human adipose-derived stromal cell and endothelial progenitor cell mixture was not superior to individual cell type transplantation in improving left ventricular function in rats with myocardial infarction.
International journal of cardiology. 164(2):205-11 [DOI] 10.1016/j.ijcard.2011.06.128. [PMID] 21794931.
Phase II clinical research design in cardiology: learning the right lessons too well: observations and recommendations from the Cardiovascular Cell Therapy Research Network (CCTRN).
Circulation. 127(15):1630-5 [DOI] 10.1161/CIRCULATIONAHA.112.000779. [PMID] 23588961.
Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal/stem cells: a joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT).
Cytotherapy. 15(6):641-8 [DOI] 10.1016/j.jcyt.2013.02.006. [PMID] 23570660.
Potential of gallium-based leads for cardiac rhythm management devices.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2011:341-4 [DOI] 10.1109/IEMBS.2011.6090113. [PMID] 22254318.
LifeShirt acquisition system to monitor ECG from ambulatory swine and the implementation of an arrhythmia detection algorithm.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2009:4820-3 [DOI] 10.1109/IEMBS.2009.5332632. [PMID] 19963627.
IFATS collection: Human adipose tissue-derived stem cells induce angiogenesis and nerve sprouting following myocardial infarction, in conjunction with potent preservation of cardiac function.
Stem cells (Dayton, Ohio). 27(1):230-7 [DOI] 10.1634/stemcells.2008-0273. [PMID] 18772313.
Expression of RAC2 in endothelial cells is required for the postnatal neovascular response.
Experimental cell research. 315(2):248-63 [PMID] 19123268.
A central role for hepatocyte growth factor in adipose tissue angiogenesis.
American journal of physiology. Endocrinology and metabolism. 294(2):E336-44 [PMID] 18073323.
A population of multipotent CD34-positive adipose stromal cells share pericyte and mesenchymal surface markers, reside in a periendothelial location, and stabilize endothelial networks.
Circulation research. 102(1):77-85 [PMID] 17967785.
In vitro clonal analysis of murine pluripotent stem cells isolated from skeletal muscle and adipose stromal cells.
Experimental hematology. 36(2):224-34 [PMID] 18023524.
Urokinase gene transfer augments angiogenesis in ischemic skeletal and myocardial muscle.
Molecular therapy : the journal of the American Society of Gene Therapy. 15(11):1939-46 [PMID] 17653104.
Suppression of hepatocyte growth factor production impairs the ability of adipose-derived stem cells to promote ischemic tissue revascularization.
Stem cells (Dayton, Ohio). 25(12):3234-43 [PMID] 17901400.
Acute myocardial infarction in swine rapidly and selectively releases highly proliferative endothelial colony forming cells (ECFCs) into circulation.
Cell transplantation. 16(9):887-97 [PMID] 18293887.
[Adipose stromal cells–plastic type of cells with high therapeutic potential].
Tsitologiia. 48(2):83-94 [PMID] 16737175.
[Adipose tissue stromal cells — multipotent cells with therapeutic potential for stimulation of angiogenesis in tissue ischemia].
Kardiologiia. 46(6):53-63 [PMID] 16883224.
Adipose tissue production of hepatocyte growth factor contributes to elevated serum HGF in obesity.
American journal of physiology. Endocrinology and metabolism. 291(4):E843-8 [PMID] 16757549.
Endothelial-monocyte-activating polypeptide II induces migration of endothelial progenitor cells via the chemokine receptor CXCR3.
Experimental hematology. 34(8):1125-32 [PMID] 16863920.
Vascular injury response in mice is dependent on genetic background.
American journal of physiology. Heart and circulatory physiology. 290(3):H1307-10 [PMID] 16214836.
Stent-based nitric oxide delivery reducing neointimal proliferation in a porcine carotid overstretch injury model.
Cardiovascular and interventional radiology. 28(1):60-5 [PMID] 15719180.
Enhancing myocardial plasmid expression by retrograde coronary venous delivery.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. 65(4):528-34 [PMID] 16003788.
Radiolabeled cell distribution after intramyocardial, intracoronary, and interstitial retrograde coronary venous delivery: implications for current clinical trials.
Circulation. 112(9 Suppl):I150-6 [PMID] 16159808.
Angiostatin is negatively associated with coronary collateral growth in patients with coronary artery disease.
American journal of physiology. Heart and circulatory physiology. 288(5):H2042-6 [PMID] 15840902.
Balancing luminal size and smooth muscle proliferation–a key control point in atherosclerosis and arteriogenesis.
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Clonal multilineage differentiation of murine common pluripotent stem cells isolated from skeletal muscle and adipose stromal cells.
Annals of the New York Academy of Sciences. 1044:183-200 [PMID] 15958712.
Cellular approaches to tissue repair in cardiovascular disease: the more we know, the more there is to learn.
American journal of physiology. Heart and circulatory physiology. 287(2):H458-63 [PMID] 15277189.
Engineered zinc finger-activating vascular endothelial growth factor transcription factor plasmid DNA induces therapeutic angiogenesis in rabbits with hindlimb ischemia.
Circulation. 110(16):2467-75 [PMID] 15477407.
Exercise acutely increases circulating endothelial progenitor cells and monocyte-/macrophage-derived angiogenic cells.
Journal of the American College of Cardiology. 43(12):2314-8 [PMID] 15193699.
P38 MAPK mediates myocardial proinflammatory cytokine production and endotoxin-induced contractile suppression.
Shock (Augusta, Ga.). 21(2):170-4 [PMID] 14752292.
Preconditioning: evolution of basic mechanisms to potential therapeutic strategies.
Shock (Augusta, Ga.). 21(3):195-209 [PMID] 14770032.
Reduced pericardial levels of endostatin correlate with collateral development in patients with ischemic heart disease.
Journal of the American College of Cardiology. 43(8):1383-7 [PMID] 15093871.
Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells.
Circulation. 109(10):1292-8 [PMID] 14993122.
Vascular ligation response is independent of p107: stressing the role of the related p130.
American journal of physiology. Heart and circulatory physiology. 285(2):H915-8 [PMID] 12860570.
Role of pRb family members in injured carotid arteries.
Journal of vascular research. 40(1):83-4 [PMID] 12644729.
Peripheral blood “endothelial progenitor cells” are derived from monocyte/macrophages and secrete angiogenic growth factors.
Circulation. 107(8):1164-9 [PMID] 12615796.
Obesity is associated with increased levels of circulating hepatocyte growth factor.
Journal of the American College of Cardiology. 41(8):1408-13 [PMID] 12706940.
A novel percutaneous technique for accessing the normal pericardium: a single-center successful experience of 53 porcine procedures.
The Journal of invasive cardiology. 15(1):13-7 [PMID] 12499522.
From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part II.
Circulation. 108(15):1772-8 [PMID] 14557340.
Widespread regional myocardial transfection by plasmid encoding Del-1 following retrograde coronary venous delivery.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. 58(2):207-11 [PMID] 12552546.
Intrapericardial ethanol delivery inhibits neointimal proliferation after porcine coronary overstretch.
Journal of the Chinese Medical Association : JCMA. 66(11):637-42 [PMID] 14768850.
From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I.
Circulation. 108(14):1664-72 [PMID] 14530185.
Stent-based approach for ventricle-to-coronary artery bypass.
Circulation. 106(8):1000-6 [PMID] 12186807.
Smooth muscle-specific expression of SV40 large TAg induces SMC proliferation causing adaptive arterial remodeling.
American journal of physiology. Heart and circulatory physiology. 283(6):H2714-24 [PMID] 12388294.
Augmentation of intrapericardial nitric oxide level by a prolonged-release nitric oxide donor reduces luminal narrowing after porcine coronary angioplasty.
Circulation. 105(23):2779-84 [PMID] 12057994.
Direct evidence for the importance of p130 in injury response and arterial remodeling following carotid artery ligation.
Cardiovascular research. 54(3):676-83 [PMID] 12031714.
Advantages of short-lived positron-emitting radioisotopes for intracoronary radiation therapy with liquid-filled balloons to prevent restenosis.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 42(9):1375-83 [PMID] 11535728.
Improved laser-assisted vascular tissue fusion using light-activated surgical adhesive in a porcine model.
Biomedical sciences instrumentation. 37:451-6 [PMID] 11347433.
Liquid-filled balloon brachytherapy using (68)Ga is effective and safe because of the short 68-minute half-life: results of a feasibility study in the porcine coronary overstretch model.
Circulation. 103(13):1793-8 [PMID] 11282912.
Differences in the effects of HMG-CoA reductase inhibitors on proliferation and viability of smooth muscle cells in culture.
Atherosclerosis. 150(2):331-41 [PMID] 10856525.
Intrapericardial paclitaxel delivery inhibits neointimal proliferation and promotes arterial enlargement after porcine coronary overstretch.
Circulation. 102(13):1575-81 [PMID] 11004150.
p75(NTR) mediates neurotrophin-induced apoptosis of vascular smooth muscle cells.
The American journal of pathology. 157(4):1247-58 [PMID] 11021829.
Studies of renal injury III: lipid-induced nephropathy in type II diabetes.
Kidney international. 57(1):92-104 [PMID] 10620191.
Pharmacokinetics and consistency of pericardial delivery directed to coronary arteries: direct comparison with endoluminal delivery.
Clinical cardiology. 22(1 Suppl 1):I10-6 [PMID] 9929762.
NGF activates similar intracellular signaling pathways in vascular smooth muscle cells as PDGF-BB but elicits different biological responses.
Arteriosclerosis, thrombosis, and vascular biology. 19(4):1041-50 [PMID] 10195934.
Hyperplasia in multiple smooth muscle tissues in transgenic mice expressing a temperature-sensitive SV40 T-antigen under the control of smooth muscle alpha-actin regulatory sequences.
Oncogene. 18(25):3773-82 [PMID] 10391686.
Efficient in vivo catheter-based pericardial gene transfer mediated by adenoviral vectors.
Clinical cardiology. 22(1 Suppl 1):I23-9 [PMID] 9929764.
Establishment of a clinically correlated human pericardial fluid bank: evaluation of intrapericardial diagnostic potential.
Clinical cardiology. 22(1 Suppl 1):I40-2 [PMID] 9929767.
Gene therapy for restenosis: getting nearer the heart of the matter.
Circulation research. 82(3):295-305 [PMID] 9486657.
Heparin responsiveness in vitro as a prognostic tool for vascular graft stenosis: a tale of two cell types?
Circulation. 97(25):2486-90 [PMID] 9657465.
Activation of MAP kinase in vivo follows balloon overstretch injury of porcine coronary and carotid arteries.
Circulation research. 81(6):904-10 [PMID] 9400370.
Effect of atherosclerosis on transmural convection an arterial ultrastructure. Implications for local intravascular drug delivery.
Arteriosclerosis, thrombosis, and vascular biology. 17(12):3365-75 [PMID] 9437181.
Vascular repair mechanisms after directional atherectomy or percutaneous transluminal coronary angioplasty in atherosclerotic rabbit iliac arteries.
American heart journal. 132(1 Pt 1):13-22 [PMID] 8701854.
Seminars in interventional cardiology : SIIC. 1(1):48-50 [PMID] 9552493.
Methods of local gene delivery to vascular tissues.
Seminars in interventional cardiology : SIIC. 1(3):215-23 [PMID] 9552514.
Human surfactant protein A enhances attachment of Pneumocystis carinii to rat alveolar macrophages.
American journal of respiratory cell and molecular biology. 14(3):232-8 [PMID] 8845173.
Microparticle deposition in periarterial microvasculature and intramural dissections after porous balloon delivery into atherosclerotic vessels: quantitation and localization by confocal scanning laser microscopy.
American heart journal. 131(5):892-8 [PMID] 8615307.
Local delivery of biodegradable microparticles containing colchicine or a colchicine analogue: effects on restenosis and implications for catheter-based drug delivery.
Journal of the American College of Cardiology. 26(6):1549-57 [PMID] 7594084.
Pharmacokinetics of adenoviral vector-mediated gene delivery to vascular smooth muscle cells: modulation by poloxamer 407 and implications for cardiovascular gene therapy.
Human gene therapy. 6(1):41-53 [PMID] 7703286.
Regional and arterial localization of radioactive microparticles after local delivery by unsupported or supported porous balloon catheters.
American heart journal. 129(5):852-9 [PMID] 7732972.
Vascular injury, repair, and restenosis after percutaneous transluminal angioplasty in the atherosclerotic rabbit.
Circulation. 92(10):2995-3005 [PMID] 7586270.
Biodegradable microspheres containing a colchicine analogue inhibit DNA synthesis in vascular smooth muscle cells.
Circulation. 89(5):1929-33 [PMID] 8181114.
8-Methoxypsoralen and longwave ultraviolet irradiation are a novel antiproliferative combination for vascular smooth muscle.
Circulation. 87(1):184-91 [PMID] 8419006.
Effects of thiol protease inhibitors on cell cycle and proliferation of vascular smooth muscle cells in culture.
Circulation research. 72(2):413-23 [PMID] 8418992.
Direct intraarterial wall injection of microparticles via a catheter: a potential drug delivery strategy following angioplasty.
American heart journal. 122(4 Pt 1):1136-40 [PMID] 1833964.
Vascular smooth muscle. A review of the molecular basis of contractility.
Circulation. 83(2):382-90 [PMID] 1991362.
Current concepts of left ventricular pseudoaneurysm: pathophysiology, therapy, and diagnostic imaging methods.
Clinical cardiology. 12(9):531-40 [PMID] 2676292.
Molecular cardiology: new avenues for the diagnosis and treatment of cardiovascular disease.
Journal of the American College of Cardiology. 13(2):265-82 [PMID] 2643653.
Effects of intraoperative glucose on protein catabolism and plasma glucose levels in patients with supratentorial tumors.
Anesthesiology. 64(4):453-9 [PMID] 3516017.
Dec 2020 ACTIVE
IPA for Stephanie Merfeld-Clauss
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
Mar 2019 ACTIVE
Combination of Secretome from Electrically Stimulated ASCs and Injectable ECM Scaffolds as Potential SCI Therapy
Role: Project Manager
Funding: NATL INST OF HLTH NINDS
Jan 2019 ACTIVE
Miscellaneous Donors Project
Role: Principal Investigator
Funding: MISCELLANEOUS DONORS
Dec 2018 – Nov 2020
IPA for Stephanie Merfeld-Clauss
Funding: US DEPT OF VET AFF GAINESVILLE MED CTR
Jun 2018 ACTIVE
OR-DRPD-ROF2018: Perfusable Magnetic Cryoprotecting Agents for Heart Biobanking
Funding: UF RESEARCH
Sep 2017 ACTIVE
Women's Ischemia Trial to Reduce Events in Non-Obstructive CAD (WARRIOR)
Role: Project Manager
Funding: US ARMY MED RES ACQUISITION
Jul 2017 – Jun 2019
Adipose Stem Cell Secretome Provides Novel Functional and Molecular Cardiac Preservation
Role: Principal Investigator
Funding: AMER HEART ASSOCIATION
IDH3931 Interdisciplinary Junior Honors
MDT7090 Elective Topics